Published in
Public Library of Science, PLoS ONE, 12(4), p. e8540, 2009
DOI: 10.1371/journal.pone.0008540
Links
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- Public Library of Science
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Streptococcus pneumoniae Coinfection Is Correlated with the Severity of H1N1 Pandemic Influenza
,
Mady Hornig,
Daniel Cisterna,
Nazir Savji,
Ana Valeria Bussetti,
Vishal Kapoor,
Jeffrey Hui,
Rafal Tokarz,
Thomas Briese,
Elsa Baumeister,
W. Ian Lipkin,
W. Ian Lipkin
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Abstract
Initial reports in May 2009 of the novel influenza strain H1N1pdm estimated a case fatality rate (CFR) of 0.6%, similar to that of seasonal influenza. In July 2009, however, Argentina reported 3056 cases with 137 deaths, representing a CFR of 4.5%. Potential explanations for increased CFR included virus reassortment or genetic drift, or infection of a more vulnerable population. Virus genomic sequencing of 26 Argentinian samples representing both severe and mild disease indicated no evidence of reassortment, mutations associated with resistance to antiviral drugs, or genetic drift that might contribute to virulence. Furthermore, no evidence was found for increased frequency of risk factors for H1N1pdm disease.