Published in

Springer Nature [academic journals on nature.com], Cell Research, 3(21), p. 435-441, 2011

DOI: 10.1038/cr.2011.26

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Epigenetic inheritance: Uncontested?

Journal article published in 2011 by Bing Zhu, Danny Reinberg ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

“Epigenetics” is currently defined as “the inheritance of variation (-genetics) above and beyond (epi-) changes in the DNA sequence”. Despite the fact that histones are believed to carry important epigenetic information, little is known about the molecular mechanisms of the inheritance of histone-based epigenetic information, including histone modifications and histone variants. Here we review recent progress and discuss potential models for the mitotic inheritance of histone modifications-based epigenetic information.