Published in
American Chemical Society, Molecular Pharmaceutics, 8(11), p. 2592-2599, 2014
DOI: 10.1021/mp400643p
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- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Carboxymethylcellulose-Based and Docetaxel-Loaded Nanoparticles Circumvent P-Glycoprotein-Mediated Multidrug Resistance
Journal article published in 2014 by
Aniruddha Roy,
Mami Murakami,
Mark J. Ernsting,
Bryan Hoang,
Elijus Undzys,
Shyh-Dar Li 
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Abstract
Taxanes are a class of anticancer agents with a broad spectrum and have been widely used to treat a variety of cancer. However, its long term use has been hampered by accumulating toxicity and development of drug resistance. The most extensively reported mechanism of resistance is the overexpression of P-glycoprotein (Pgp).