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Public Library of Science, PLoS ONE, 10(8), p. e77303, 2013

DOI: 10.1371/journal.pone.0077303

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An Integrated Approach Based on Multiplexed Protein Array and iTRAQ Labeling for In-Depth Identification of Pathways Associated to IVF Outcome

Journal article published in 2013 by Valeria Severino, Livia Malorni, Anna Emilia Cicatiello, Vittoria D’Esposito, Vittoria D’Esposito ORCID, Salvatore Longobardi, Nicola Colacurci, Nadia Miraglia, Nicola Sannolo, Annarita Farina, Angela Chambery
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The emergence of high-throughput protein quantification methodologies has enabled the comprehensive characterization by longitudinal and cross-sectional studies of biological fluids under physiological and pathological conditions. In particular, the simultaneous investigation of cytokines and growth factors signaling pathways and their associated downstream effectors by integrated multiplexed approaches offers a powerful strategy to gain insights into biological networks and processes in living systems. A growing body of research indicates that bioactive molecules of human reproductive fluids, including human follicular fluid (hFF), may affect oocyte quality, fertilization and embryo development, thus potentially influencing the physiopathology of pregnancy-related conditions.