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Oxford University Press (OUP), The Journal of Infectious Diseases, 3(205), p. 376-383
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Variants in the ITPA Gene Protect Against Ribavirin-Induced Hemolytic Anemia in HIV/HCV-Coinfected Patients With All HCV Genotypes
Journal article published in 2011 by
Susanna Naggie,
Norma I. Rallon,
José M. Benito 
,
Judith Morello,
Sonia Rodriguez-Novoa,
Paul J. Clark,
Alexander J. Thompson,
Kevin V. Shianna,
Eugenia Vispo,
John G. McHutchison,
David B. Goldstein,
Vincent Soriano
,
Judith Morello,
Sonia Rodriguez-Novoa,
Paul J. Clark,
Alexander J. Thompson,
Kevin V. Shianna,
Eugenia Vispo,
John G. McHutchison,
David B. Goldstein,
Vincent Soriano
This paper is made freely available by the publisher.
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Abstract
Background. A recent genome-wide association study reported a strong association with a single-nucleotide polymorphism (SNP) in the inosine triphosphate (ITPA) gene and hemolytic anemia in patients infected with hepatitis C virus (HCV) receiving pegylated interferon and ribavirin. We investigate these polymorphisms in a cohort of human immunodeficiency virus (HIV)/HCV–coinfected patients.