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American Chemical Society, Biomacromolecules, 9(13), p. 2609-2615, 2012

DOI: 10.1021/bm3009445

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Water-Soluble Poly(L-serine)s with Elongated and Charged Side-Chains: Synthesis, Conformations and Cell-Penetrating Properties

Journal article published in 2012 by Haoyu Tang, Lichen Yin, Hua Lu ORCID, Jianjun Cheng
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Water-soluble poly(L-serine)s bearing long side-chain with terminal charge groups were synthesized via ring-opening polymerization of O-pentenyl-L-serine N-carboxyanhydride followed by thiol-ene reactions. These side-chain modified poly(L-serine)s adopt β-sheet conformation in aqueous solution with excellent stability against changes in pH and temperature. These water-soluble poly(L-serine) derivatives with charged side-chain functional groups and stable β-sheet conformations showed membrane-penetrating capabilities in different cell lines with low cytotoxicity.