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Springer Nature [academic journals on nature.com], Molecular Psychiatry, 2(18), p. 264-264, 2013

DOI: 10.1038/mp.2012.36

Springer Nature [academic journals on nature.com], Molecular Psychiatry, 2(18), p. 255-263, 2011

DOI: 10.1038/mp.2011.148

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A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene

Journal article published in 2011 by A. Papassotiropoulos, E. Stefanova, C. Vogler ORCID, L. Gschwind, S. Ackermann, K. Spalek, Bj Rasch, A. Heck, A. Aerni, E. Hanser, P. Demougin, D. J.-F. de Quervain, K.-D. Huynh, Huynh Kd, R. Luechinger and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10(-8)) associated with verbal memory performance in a cognitively healthy cohort from Switzerland (n=1073) and was replicated in a second cohort from Serbia (n=524; P=0.003). Gene expression studies showed CTNNBL1 genotype-dependent differences in beta-catenin-like protein 1 mRNA levels in the human cortex. Functional magnetic resonance imaging in 322 subjects detected CTNNBL1 genotype-dependent differences in memory-related brain activations. Converging evidence from independent experiments and different methodological approaches suggests a role for CTNNBL1 in human memory.Molecular Psychiatry advance online publication, 22 November 2011; doi:10.1038/mp.2011.148.