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Wiley, British Journal of Clinical Pharmacology, 6(66), p. 866-874, 2008

DOI: 10.1111/j.1365-2125.2008.03292.x

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The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women

Journal article published in 2008 by Anouk E. Muller, P. Joep Dörr, Johan W. Mouton ORCID, Joost De Jongh, Paul M. Oostvogel, Eric A. P. Steegers, Rob A. Voskuyl, Meindert Danhof
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECTExamples exist that pharmacokinetics of drugs in pregnant women can differ from that in non-pregnant individuals.In pregnant women before the onset of labour, the pharmacokinetics of amoxicillin is similar to that in non-pregnant individuals, but for women during labour this is unknown. WHAT THIS STUDY ADDSLabour influences the pharmacokinetics of amoxicillin.During labour and even more in the immediate postpartum period, the peripheral volume of distribution was decreased compared with pregnant women before the onset of labour.The volume of distribution increases with an increasing amount of oedema.