Published in

De Gruyter Open, Open Physics, 9(12), 2014

DOI: 10.2478/s11534-014-0497-0

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Self-regulating genes. Exact steady state solution by using Poisson representation

Journal article published in 2014 by István P. Sugár, István Simon ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractSystems biology studies the structure and behavior of complex gene regulatory networks. One of its aims is to develop a quantitative understanding of the modular components that constitute such networks. The self-regulating gene is a type of auto regulatory genetic modules which appears in over 40% of known transcription factors in E. coli. In this work, using the technique of Poisson Representation, we are able to provide exact steady state solutions for this feedback model. By using the methods of synthetic biology (P.E.M. Purnick and Weiss, R., Nature Reviews, Molecular Cell Biology, 2009, 10: 410–422) one can build the system itself from modules like this.