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Ivyspring International Publisher, Journal of Cancer, 9(5), p. 745-753

DOI: 10.7150/jca.9696

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cMET Activation and EGFR-Directed Therapy Resistance in Triple-Negative Breast Cancer

Journal article published in 2014 by Joohyuk Sohn ORCID, Shuying Liu, Napa Parinyanitikul, Jangsoon Lee, Gabriel N. Hortobagyi, Gordon B. Mills, Naoto T. Ueno, Ana M. Gonzalez-Angulo
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: EGFR expression and pathway activation are common in triple-negative breast cancer (TNBC). However, anti-EGFR therapies have not been effective in these patients. We aimed to study the efficacy of targeting MET in overcoming resistance to EGFR therapy in TNBC cell lines.