Dissemin is shutting down on January 1st, 2025

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Elsevier, Progress in Biophysics and Molecular Biology, 2-3(115), p. 162-172, 2014

DOI: 10.1016/j.pbiomolbio.2014.06.008

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Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline

Journal article published in 2014 by David Benoist, Rachel Stones, Alan P. Benson, Ewan D. Fowler, Mark J. Drinkhill, Matthew E. L. Hardy, David A. Saint, Olivier Bernus, Olivier Cazorla ORCID, Ed White
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This paper is available in a repository.

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Abstract

We demonstrate the synergistic benefits of using multiple technologies to investigate complex multi-scale biological responses. The combination of reductionist and integrative methodologies can reveal novel insights into mechanisms of action by tracking changes of in vivo phenomena to alterations in protein activity (or vice versa). We have applied this approach to electrical and mechanical remodelling in right ventricular failure caused by monocrotaline-induced pulmonary artery hypertension in rats.