Published in
Elsevier, Bioorganic and Medicinal Chemistry, 19(17), p. 7008-7014, 2009
DOI: 10.1016/j.bmc.2009.08.001
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δ-Di-carboxybutyl phosphoramidate of 2′-deoxycytidine-5′-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase
Journal article published in 2009 by
Ivan Zlatev,
Anne Giraut,
François Morvan 
,
Piet Herdewijn,
Jean-Jacques Vasseur
,
Piet Herdewijn,
Jean-Jacques Vasseur
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Abstract
The replacement of the pyrophosphate moiety of 2'-deoxynucleoside triphosphates by non natural delta-dicarboxylic butyl amino acid allows incorporation of natural 2'-deoxycytidine into DNA using HIV-1 reverse transcriptase (RT) as enzyme. In contrast, the 3'-deoxycytidine analogue was not a substrate of the HIV-1 RT.