Dissemin is shutting down on January 1st, 2025

Published in

Elsevier, Neurobiology of Disease, (97), p. 127-138, 2017

DOI: 10.1016/j.nbd.2016.03.025

Links

Tools

Export citation

Search in Google Scholar

Neurotrophic factors and their inhibitors in chronic pain treatment

Journal article published in 2016 by Jayne H. Kelleher, Damini Tewari ORCID, Stephen B. McMahon
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been identified as therapeutic targets to improve current treatments of chronic pain. This review article focuses on nerve growth factor (NGF) and interleukin-6 (IL-6) as potential therapeutic targets. In this review we highlight the mechanisms of action and the current progress of targeted therapies in clinical trials.