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Nature Research, Nature Genetics, 4(48), p. 356-358, 2016

DOI: 10.1038/ng.3503

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Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer

Journal article published in 2016 by Hikmat A. Al Ahmadie, Gopa Iyer ORCID, Byron H. Lee, Sasinya N. Scott, Rohit Mehra, Aditya Bagrodia, Emmet J. Jordan, Sizhi Paul Gao, Ricardo Ramirez, Eugene K. Cha ORCID, Neil B. Desai, Emily C. Zabor, Irina Ostrovnaya, Anuradha Gopalan, Ying-Bei Chen and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration.