Dissemin is shutting down on January 1st, 2025

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Wiley, ChemBioChem, 15(13), p. 2209-2211, 2012

DOI: 10.1002/cbic.201200464

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The α-Ketoglutarate/Fe(II)-dependent Dioxygenase VldW is Responsible for the Formation of Validamycin B

Journal article published in 2012 by Khaled H. Almabruk, Shumpei Asamizu, Ada Chang, Sheril G. Varghese, Taifo Mahmud ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

From A to B: Through detailed biochemical investigations, we discovered that VldW, an α-ketoglutarate/Fe(II) -dependent dioxygenase, regioselectively hydroxylates validamycin A to validamycin B. The results provide insights into the biosynthesis of hydroxylated validamycins and could be used to control the metabolic outcomes of the validamycin pathway.