Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

Van Rensburg, E. J.; Yg, Lin; Kuchenbaecker, Karoline B.; Tyrer, Jonathan; Spindler, Tassja J.; Ramus, Susan J.; Terry, Mb; Terry, Mary Beth; Shen, Howard C.; Southey, Melissa; van Rensburg, Elizabeth J.; Sj, Ramus; Registry, Breast Cancer Family; Lee, Janet M.; Sunde, Lone; Lin, Yvonne G.; Skytte, Anne-Bine; Coetzee, Simon; Weitzel, Jeffrey N.; Li, Qiyuan; Goldgar, David E.; Miron, Alexander; Buys, Saundra Ss; Hazelett, Dennis; Viel, Alessandra; Tj, Spindler; Janavicius, Ramunas; Dorfling, Cecilia M.; Neuhausen, Susan L.; Ding, Yuan Chun; Hansen, Thomas V. O.; Beesley, Jonathan; Jonson, Lars; Gerdes, Anne-Marie; de la Hoya, Miguel; Ejlertsen, Bent; Schmutzler, Rita Katharina; Barrowdale, Daniel; Osorio, Ana; Dennis, Joe; Sutter, Christian; Lawrenson, Kate; Sinilnikova, Olga M.; Benitez, Javier; Peterlongo, Paolo; Stoppa-Lyonnet, Dominique; Garcia, Maria Jose; Pejovic, Tanja; Komenaka, Ian; Peissel, Bernard; Ganschow, Pamela; McGuffog, Lesley; Rodriguez, Gustavo C.; Manoukian, Siranoush; Bean, Yukie; Bernard, Loris; Radice, Paolo; Bonanni, Bernardo; Papi, Laura; Healey, Sue; Ottini, Laura; Rookus, Matti A.; Fostira, Florentia; Tihomirova, Laima; Perkins, Jo; Tung, Nadine; Konstantopoulou, Irene; Platte, Radka; Garber, Judy; Tischkowitz, Marc; Frost, Debra; Meindl, Alfons; Ellis, Steve; Godwin, Andrew K.; Wang, Xianshu; Engel, Christoph; Vijai, Joseph; Mazoyer, Sylvie; Simard, Jacques; Soucy, Penny; Sukiennicki, Grzegorz; Tognazzo, Silvia; Claes, Kathleen; Teixeira, Manuel R.; Damiola, Francesca; De Leeneer, Kim; Piedmonte, Marion; O'Malley, David M.; Kirk, Judy; Szabo, Csilla I.; Caldes, Trinidad; Nevanlinna, Heli; Zidan, Jamal; Oosterwijk, Jan C.; Tea, Muy-Kheng; Singer, Christian F.; du Bois, Andreas; Hamann, Ute; Isaccs, Claudine; Tchatchou, Sandrine; Imyanitov, Evgeny N.; Rennert, Gad; De La Hoya, M.; Olah, Edith; Caligo, Maria A.; Plante, Marie; Aittomäki, Kristiina; Campbell, Ian G.; Toland, Amanda Ewart; Barkardottir, Rosa B.; Hogervorst, Frans B. L.; Walsh, Christine; Thomassen, Mads; Montagna, Marco; Margriet Collée, J.; Diez, Orland; Blanco, Ignacio; Brunet, Joan; Soller, Maria; Pankratz, Vernon S.; Van Nieuwenhuysen, Els; Vergote, Ignace; Jakubowska, Anna; van Altena, Anne M.; Stenmark-Askmalm, Marie; Gronwald, Jacek; Kb, Kuchenbaecker; Wicklund, Kristine G.; Rebbeck, Timothy R.; Lubinski, Jan; Lindor, Noralane; Pujana, Miquel Angel; Pfeiler, Georg; Wang-Gohrke, Shan; Kauff, Noah; Phelan, Catherine M.; Wilkens, Lynne R.; Aghajanian, Carol A.; Van Altena, A. M.; Mai, Phuong L.; Lazaro, Conxi; Berger, Andreas; Mulligan, Anna Marie; Greene, Mark H.; Rossing, Mary Anne; Lee, Andrew W.; Rudolph, Anja; Andrulis, Irene L.; Glendon, Gord; Jensen, Uffe Birk; Sucheston, Lara; Kruse, Torben A.; Bojesen, Anders; Thompson, Pamela J.; Shvetsov, Yurii B.; Friedman, Eitan; Olopade, Olufunmilayo I.; Laitman, Yael; Runnebaum, Ingo B.; Nussbaum, Robert L.; Liljegren, Annelie; Nathanson, Katherine L.; Woo, Yin-Ling; Lee, Alice W.; Aittomaeki, Kristiina; Arver, Brita; Jønson, Lars; Einbeigi, Zakaria; Vierkant, Robert A.; Schwaab, Ira; Domchek, Susan M.; Lu, Karen H.; Wu, Xifeng; Karlan, Beth Y.; Teo, Soo-Hwang; Jose Garcia, Maria; Lester, Jenny; Weber, Rachel Palmieri; Ekici, Arif B.; Hein, Alexander; Collée, Jm Margriet; Lee, Jm; Beckmann, Matthias W.; Fasching, Peter A.; Pelttari, Liisa M.; Lambrechts, Diether; Modugno, Francesmary; Lambrechts, Sandrina; Angel Pujana, Miguel; Leminen, Arto; Dicks, Ed; Schildkraut, Joellen M.; Moysich, Kirsten B.; Ness, Roberta B.; Doherty, Jennifer A.; Lazaroso, Conxi; Butzow, Ralf; Terry, Kathryn L.; Odunsi, Kunle; ,; Tworoger, Shelley Ss; Chang-Claude, Jenny; Kelley, Joseph L.; Edwards, Robert P.; Eilber, Ursula; Matsuo, Keitaro; Salvesen, Helga B.; Yang, Hannah; Tangen, Ingvild L.; Heitz, Florian; Orsulic, Sandra; Lele, Shashi; Wentzensen, Nicolas; Goodman, Marc T.; Harter, Philipp; Embrace, Godwin Ak; Hosono, Satoyo; Hillemanns, Peter; Jensen, Allan; Zheng, Wei; Whittemore, Alice S.; Antonenkova, Natalia; Kjaer, Susanne Krüger; Hogdall, Estrid; Bogdanova, Natalia; Hasmad, Hanis Nazihah; Hc, Shen; Azmi, Mat Adenan Noor; Song, Honglin; Fridley, Brooke L.; Goode, Ellen L.; Siddiqui, Nadeem; Cunningham, Julie M.; Ziogas, Argyrios; Rothstein, Joseph H.; Bruinsma, Fiona; Sieh, Weiva; Giles, Graham Gg; Poole, Elizabeth M.; Liang, Dong; Shu, Xiao-Ou; Dürst, Matthias; Hildebrandt, Michelle A. T.; Wu, Anna H.; Rosen, Barry; Dörk, Thilo; Orlow, Irene; Risch, Harvey A.; Levine, Douglas A.; Bisogna, Maria; Olson, Sara H.; Investigators, KConFab; Berchuck, Andrew; Iversen, Edwin S.; Concannon, Patrick; Sellers, Thomas A.; Collaborators, Gemo Study; Tsai, Ya-Yu; Cramer, Daniel W.; Du Bois, A.; Bandera, Elisa V.; Massuger, Leon F. A. G.; Duerst, Matthias; Krakstad, Camilla; Bjorge, Line; Doerk, Thilo; Hebon, Olah E.; Aben, Katja K. H.; Kiemeney, Lambertus A.; Timorek, Agnieszka; Kellar, Melissa; Brooks-Wilson, Angela; Rzepecka, Iwona K.; Kelemen, Linda E.; Nedergaard, Lotte; Cook, Linda S.; Le, Nhu D.; McNeish, Ian; Cybulski, Cezary; Pasini, Barbara; Lissowska, Jolanta; Paul, James; Brinton, Louise A.; Hogdall, Claus; Lundvall, Lene; McGuire, Valerie; Baker, Helen; Campbe, Ig; Eccles, Diana; Carty, Karen; Glasspool, Rosalind; McLaughlin, John R.; Narod, Steven A.; Ji, Bu-Tian; Monteiro, Alvaro N.; Gao, Yu-Tang; Permuth-Wey, Jenny; Parsons, Pg; Chen, Ann; Menon, Usha; Lin, Hui-Yi; Chen, Zhihua; Lázaro, Conxi; Pearce, Celeste L.; Anton-Culver, Hoda; Gemo, Study Collaborators; Gentry-Maharaj, Aleksandra; Pike, Malcolm C.; Harrington, Patricia; Coetzee, Gerry; Dansonka-Mieszkowska, Agnieszka; Noushmehr, Houtan; Kupryjanczyk, Jolanta; Offit, Kenneth; Freedman, Matt; Brca1 and Brca2, the Consortium of Investigators of Modifiers of; Investigators), Australian Cancer Study (Ovarian; Easton, Douglas F.; Pharoah, Paul Pp; Couch, Fergus J.; Group, Australian Ovarian Cancer Study; Gayther, Simon; Antoniou, Antonis C.; Høgdall, Estrid; Chenevix-Trench, Georgia; Consortium of Investigators of Modifiers of Brca1 and BRCA2 (CIMBA) (Lone Sunde, Anne-Bine Semma Skytte members of-); Machackova, Eva

Dissemin
Susan Ramus
Van Rensburg et al., 2015

Published in

Nature Research, Nature Genetics, 2(47), p. 164-171, 2015

DOI: 10.1038/ng.3185

Tools

Export citation

Format

@article{Van Rensburg2015,
  abstract = {Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P &lt; 5 × 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.},
  author = {Van Rensburg, E. J. and Yg, Lin and Kuchenbaecker, Karoline B. and Tyrer, Jonathan and Spindler, Tassja J. and Ramus, Susan J. and Terry, Mb and Terry, Mary Beth and Shen, Howard C. and Southey, Melissa and van Rensburg, Elizabeth J. and Sj, Ramus and Registry, Breast Cancer Family and Lee, Janet M. and Sunde, Lone and Lin, Yvonne G. and Skytte, Anne-Bine and Coetzee, Simon and Weitzel, Jeffrey N. and Li, Qiyuan and Goldgar, David E. and Miron, Alexander and Buys, Saundra Ss and Hazelett, Dennis and Viel, Alessandra and Tj, Spindler and Janavicius, Ramunas and Dorfling, Cecilia M. and Neuhausen, Susan L. and Ding, Yuan Chun and Hansen, Thomas V. O. and Beesley, Jonathan and Jonson, Lars and Gerdes, Anne-Marie and de la Hoya, Miguel and Ejlertsen, Bent and Schmutzler, Rita Katharina and Barrowdale, Daniel and Osorio, Ana and Dennis, Joe and Sutter, Christian and Lawrenson, Kate and Sinilnikova, Olga M. and Benitez, Javier and Peterlongo, Paolo and Stoppa-Lyonnet, Dominique and Garcia, Maria Jose and Pejovic, Tanja and Komenaka, Ian and Peissel, Bernard and Ganschow, Pamela and McGuffog, Lesley and Rodriguez, Gustavo C. and Manoukian, Siranoush and Bean, Yukie and Bernard, Loris and Radice, Paolo and Bonanni, Bernardo and Papi, Laura and Healey, Sue and Ottini, Laura and Rookus, Matti A. and Fostira, Florentia and Tihomirova, Laima and Perkins, Jo and Tung, Nadine and Konstantopoulou, Irene and Platte, Radka and Garber, Judy and Tischkowitz, Marc and Frost, Debra and Meindl, Alfons and Ellis, Steve and Godwin, Andrew K. and Wang, Xianshu and Engel, Christoph and Vijai, Joseph and Mazoyer, Sylvie and Simard, Jacques and Soucy, Penny and Sukiennicki, Grzegorz and Tognazzo, Silvia and Claes, Kathleen and Teixeira, Manuel R. and Damiola, Francesca and De Leeneer, Kim and Piedmonte, Marion and O'Malley, David M. and Kirk, Judy and Szabo, Csilla I. and Caldes, Trinidad and Nevanlinna, Heli and Zidan, Jamal and Oosterwijk, Jan C. and Tea, Muy-Kheng and Singer, Christian F. and du Bois, Andreas and Hamann, Ute and Isaccs, Claudine and Tchatchou, Sandrine and Imyanitov, Evgeny N. and Rennert, Gad and De La Hoya, M. and Olah, Edith and Caligo, Maria A. and Plante, Marie and Aittomäki, Kristiina and Campbell, Ian G. and Toland, Amanda Ewart and Barkardottir, Rosa B. and Hogervorst, Frans B. L. and Walsh, Christine and Thomassen, Mads and Montagna, Marco and Margriet Collée, J. and Diez, Orland and Blanco, Ignacio and Brunet, Joan and Soller, Maria and Pankratz, Vernon S. and Van Nieuwenhuysen, Els and Vergote, Ignace and Jakubowska, Anna and van Altena, Anne M. and Stenmark-Askmalm, Marie and Gronwald, Jacek and Kb, Kuchenbaecker and Wicklund, Kristine G. and Rebbeck, Timothy R. and Lubinski, Jan and Lindor, Noralane and Pujana, Miquel Angel and Pfeiler, Georg and Wang-Gohrke, Shan and Kauff, Noah and Phelan, Catherine M. and Wilkens, Lynne R. and Aghajanian, Carol A. and Van Altena, A. M. and Mai, Phuong L. and Lazaro, Conxi and Berger, Andreas and Mulligan, Anna Marie and Greene, Mark H. and Rossing, Mary Anne and Lee, Andrew W. and Rudolph, Anja and Andrulis, Irene L. and Glendon, Gord and Jensen, Uffe Birk and Sucheston, Lara and Kruse, Torben A. and Bojesen, Anders and Thompson, Pamela J. and Shvetsov, Yurii B. and Friedman, Eitan and Olopade, Olufunmilayo I. and Laitman, Yael and Runnebaum, Ingo B. and Nussbaum, Robert L. and Liljegren, Annelie and Nathanson, Katherine L. and Woo, Yin-Ling and Lee, Alice W. and Aittomaeki, Kristiina and Arver, Brita and Jønson, Lars and Einbeigi, Zakaria and Vierkant, Robert A. and Schwaab, Ira and Domchek, Susan M. and Lu, Karen H. and Wu, Xifeng and Karlan, Beth Y. and Teo, Soo-Hwang and Jose Garcia, Maria and Lester, Jenny and Weber, Rachel Palmieri and Ekici, Arif B. and Hein, Alexander and Collée, Jm Margriet and Lee, Jm and Beckmann, Matthias W. and Fasching, Peter A. and Pelttari, Liisa M. and Lambrechts, Diether and Modugno, Francesmary and Lambrechts, Sandrina and Angel Pujana, Miguel and Leminen, Arto and Dicks, Ed and Schildkraut, Joellen M. and Moysich, Kirsten B. and Ness, Roberta B. and Doherty, Jennifer A. and Lazaroso, Conxi and Butzow, Ralf and Terry, Kathryn L. and Odunsi, Kunle and ,  and Tworoger, Shelley Ss and Chang-Claude, Jenny and Kelley, Joseph L. and Edwards, Robert P. and Eilber, Ursula and Matsuo, Keitaro and Salvesen, Helga B. and Yang, Hannah and Tangen, Ingvild L. and Heitz, Florian and Orsulic, Sandra and Lele, Shashi and Wentzensen, Nicolas and Goodman, Marc T. and Harter, Philipp and Embrace, Godwin Ak and Hosono, Satoyo and Hillemanns, Peter and Jensen, Allan and Zheng, Wei and Whittemore, Alice S. and Antonenkova, Natalia and Kjaer, Susanne Krüger and Hogdall, Estrid and Bogdanova, Natalia and Hasmad, Hanis Nazihah and Hc, Shen and Azmi, Mat Adenan Noor and Song, Honglin and Fridley, Brooke L. and Goode, Ellen L. and Siddiqui, Nadeem and Cunningham, Julie M. and Ziogas, Argyrios and Rothstein, Joseph H. and Bruinsma, Fiona and Sieh, Weiva and Giles, Graham Gg and Poole, Elizabeth M. and Liang, Dong and Shu, Xiao-Ou and Dürst, Matthias and Hildebrandt, Michelle A. T. and Wu, Anna H. and Rosen, Barry and Dörk, Thilo and Orlow, Irene and Risch, Harvey A. and Levine, Douglas A. and Bisogna, Maria and Olson, Sara H. and Investigators, KConFab and Berchuck, Andrew and Iversen, Edwin S. and Concannon, Patrick and Sellers, Thomas A. and Collaborators, Gemo Study and Tsai, Ya-Yu and Cramer, Daniel W. and Du Bois, A. and Bandera, Elisa V. and Massuger, Leon F. A. G. and Duerst, Matthias and Krakstad, Camilla and Bjorge, Line and Doerk, Thilo and Hebon, Olah E. and Aben, Katja K. H. and Kiemeney, Lambertus A. and Timorek, Agnieszka and Kellar, Melissa and Brooks-Wilson, Angela and Rzepecka, Iwona K. and Kelemen, Linda E. and Nedergaard, Lotte and Cook, Linda S. and Le, Nhu D. and McNeish, Ian and Cybulski, Cezary and Pasini, Barbara and Lissowska, Jolanta and Paul, James and Brinton, Louise A. and Hogdall, Claus and Lundvall, Lene and McGuire, Valerie and Baker, Helen and Campbe, Ig and Eccles, Diana and Carty, Karen and Glasspool, Rosalind and McLaughlin, John R. and Narod, Steven A. and Ji, Bu-Tian and Monteiro, Alvaro N. and Gao, Yu-Tang and Permuth-Wey, Jenny and Parsons, Pg and Chen, Ann and Menon, Usha and Lin, Hui-Yi and Chen, Zhihua and Lázaro, Conxi and Pearce, Celeste L. and Anton-Culver, Hoda and Gemo, Study Collaborators and Gentry-Maharaj, Aleksandra and Pike, Malcolm C. and Harrington, Patricia and Coetzee, Gerry and Dansonka-Mieszkowska, Agnieszka and Noushmehr, Houtan and Kupryjanczyk, Jolanta and Offit, Kenneth and Freedman, Matt and Brca1 and Brca2, the Consortium of Investigators of Modifiers of and Investigators), Australian Cancer Study (Ovarian and Easton, Douglas F. and Pharoah, Paul Pp and Couch, Fergus J. and Group, Australian Ovarian Cancer Study and Gayther, Simon and Antoniou, Antonis C. and Høgdall, Estrid and Chenevix-Trench, Georgia and Consortium of Investigators of Modifiers of Brca1 and BRCA2 (CIMBA) (Lone Sunde, Anne-Bine Semma Skytte members of-) and Machackova, Eva},
  doi = {10.1038/ng.3185},
  journal = {Nature Genetics},
  month = {jan},
  pages = {164-171},
  title = {Identification of six new susceptibility loci for invasive epithelial ovarian cancer.},
  url = {http://www.nature.com/articles/ng.3185.pdf},
  volume = {47},
  year = {2015}
}

Download

Export citation

Search in Google Scholar

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

Journal article published in 2015 by E. J. Van Rensburg, Lin Yg, Karoline B. Kuchenbaecker, Jonathan Tyrer, Tassja J. Spindler, Susan J. Ramus

, Mb Terry, Mary Beth Terry, Howard C. Shen, Melissa Southey, Elizabeth J. van Rensburg, Ramus Sj, Breast Cancer Family Registry, Janet M. Lee, Lone Sunde and other authors. E. J. Van Rensburg, Lin Yg, Karoline B. Kuchenbaecker, Jonathan Tyrer, Tassja J. Spindler, Susan J. Ramus

, Mb Terry, Mary Beth Terry, Howard C. Shen, Melissa Southey, Elizabeth J. van Rensburg, Ramus Sj, Breast Cancer Family Registry, Janet M. Lee, Lone Sunde, Yvonne G. Lin, Anne-Bine Skytte

, Simon Coetzee, Jeffrey N. Weitzel

, Qiyuan Li, David E. Goldgar, Alexander Miron, Saundra Ss Buys, Dennis Hazelett, Alessandra Viel

, Spindler Tj, Ramunas Janavicius, Cecilia M. Dorfling, Susan L. Neuhausen, Yuan Chun Ding, Thomas V. O. Hansen, Jonathan Beesley

, Lars Jonson, Anne-Marie Gerdes, Miguel de la Hoya, Bent Ejlertsen, Rita Katharina Schmutzler, Daniel Barrowdale, Ana Osorio, Joe Dennis

, Christian Sutter, Kate Lawrenson, Olga M. Sinilnikova, Javier Benitez, Paolo Peterlongo, Dominique Stoppa-Lyonnet, Maria Jose Garcia

, Tanja Pejovic, Ian Komenaka, Bernard Peissel, Pamela Ganschow, Lesley McGuffog, Gustavo C. Rodriguez, Siranoush Manoukian

, Yukie Bean, Loris Bernard, Paolo Radice

, Bernardo Bonanni, Laura Papi, Sue Healey, Laura Ottini, Matti A. Rookus, Florentia Fostira, Laima Tihomirova, Jo Perkins, Nadine Tung, Irene Konstantopoulou, Radka Platte, Judy Garber, Marc Tischkowitz, Debra Frost, Alfons Meindl, Steve Ellis, Andrew K. Godwin, Xianshu Wang, Christoph Engel

, Joseph Vijai

, Sylvie Mazoyer, Jacques Simard, Penny Soucy, Grzegorz Sukiennicki, Silvia Tognazzo, Kathleen Claes, Manuel R. Teixeira

, Francesca Damiola

, Kim De Leeneer, Marion Piedmonte, David M. O'Malley, Judy Kirk, Csilla I. Szabo, Trinidad Caldes, Heli Nevanlinna, Jamal Zidan, Jan C. Oosterwijk, Muy-Kheng Tea, Christian F. Singer, Andreas du Bois, Ute Hamann, Claudine Isaccs, Sandrine Tchatchou, Evgeny N. Imyanitov, Gad Rennert, M. De La Hoya, Edith Olah, Maria A. Caligo, Marie Plante, Kristiina Aittomäki, Ian G. Campbell, Amanda Ewart Toland

, Rosa B. Barkardottir, Frans B. L. Hogervorst, Christine Walsh, Mads Thomassen, Marco Montagna, J. Margriet Collée, Orland Diez, Ignacio Blanco

, Joan Brunet, Maria Soller, Vernon S. Pankratz, Els Van Nieuwenhuysen, Ignace Vergote, Anna Jakubowska

, Anne M. van Altena, Marie Stenmark-Askmalm, Jacek Gronwald, Kuchenbaecker Kb, Kristine G. Wicklund, Timothy R. Rebbeck, Jan Lubinski, Noralane Lindor, Miquel Angel Pujana, Georg Pfeiler, Shan Wang-Gohrke, Noah Kauff, Catherine M. Phelan, Lynne R. Wilkens, Carol A. Aghajanian, A. M. Van Altena, Phuong L. Mai, Conxi Lazaro, Andreas Berger, Anna Marie Mulligan, Mark H. Greene

, Mary Anne Rossing, Andrew W. Lee, Anja Rudolph, Irene L. Andrulis

, Gord Glendon, Uffe Birk Jensen, Lara Sucheston, Torben A. Kruse, Anders Bojesen, Pamela J. Thompson, Yurii B. Shvetsov, Eitan Friedman, Olufunmilayo I. Olopade, Yael Laitman, Ingo B. Runnebaum, Robert L. Nussbaum, Annelie Liljegren, Katherine L. Nathanson, Yin-Ling Woo

, Alice W. Lee, Kristiina Aittomaeki, Brita Arver, Lars Jønson, Zakaria Einbeigi, Robert A. Vierkant, Ira Schwaab, Susan M. Domchek, Karen H. Lu, Xifeng Wu, Beth Y. Karlan, Soo-Hwang Teo, Maria Jose Garcia, Jenny Lester, Rachel Palmieri Weber, Arif B. Ekici

, Alexander Hein

, Jm Margriet Collée

, Jm Lee, Matthias W. Beckmann, Peter A. Fasching, Liisa M. Pelttari, Diether Lambrechts

, Francesmary Modugno, Sandrina Lambrechts, Miguel Angel Pujana, Arto Leminen, Ed Dicks, Joellen M. Schildkraut, Kirsten B. Moysich, Roberta B. Ness, Jennifer A. Doherty, Conxi Lazaroso, Ralf Butzow, Kathryn L. Terry, Kunle Odunsi, , Shelley Ss Tworoger

, Jenny Chang-Claude, Joseph L. Kelley, Robert P. Edwards, Ursula Eilber, Keitaro Matsuo

, Helga B. Salvesen, Hannah Yang, Ingvild L. Tangen, Florian Heitz, Sandra Orsulic, Shashi Lele, Nicolas Wentzensen, Marc T. Goodman, Philipp Harter, Godwin Ak Embrace, Satoyo Hosono, Peter Hillemanns, Allan Jensen, Wei Zheng, Alice S. Whittemore, Natalia Antonenkova, Susanne Krüger Kjaer, Estrid Hogdall, Natalia Bogdanova, Hanis Nazihah Hasmad, Shen Hc, Mat Adenan Noor Azmi, Honglin Song, Brooke L. Fridley

, Ellen L. Goode, Nadeem Siddiqui, Julie M. Cunningham

, Argyrios Ziogas

, Joseph H. Rothstein, Fiona Bruinsma, Weiva Sieh, Graham Gg Giles, Elizabeth M. Poole, Dong Liang, Xiao-Ou Shu, Matthias Dürst, Michelle A. T. Hildebrandt, Anna H. Wu, Barry Rosen, Thilo Dörk, Irene Orlow, Harvey A. Risch, Douglas A. Levine

, Maria Bisogna, Sara H. Olson, KConFab Investigators, Andrew Berchuck, Edwin S. Iversen, Patrick Concannon, Thomas A. Sellers, Gemo Study Collaborators, Ya-Yu Tsai, Daniel W. Cramer, A. Du Bois, Elisa V. Bandera, Leon F. A. G. Massuger, Matthias Duerst, Camilla Krakstad, Line Bjorge, Thilo Doerk, Olah E. Hebon, Katja K. H. Aben, Lambertus A. Kiemeney, Agnieszka Timorek, Melissa Kellar, Angela Brooks-Wilson, Iwona K. Rzepecka, Linda E. Kelemen, Lotte Nedergaard, Linda S. Cook, Nhu D. Le, Ian McNeish

, Cezary Cybulski, Barbara Pasini, Jolanta Lissowska, James Paul, Louise A. Brinton, Claus Hogdall, Lene Lundvall, Valerie McGuire, Helen Baker, Ig Campbe, Diana Eccles, Karen Carty, Rosalind Glasspool, John R. McLaughlin, Steven A. Narod, Bu-Tian Ji, Alvaro N. Monteiro

, Yu-Tang Gao, Jenny Permuth-Wey, Pg Parsons, Ann Chen, Usha Menon, Hui-Yi Lin, Zhihua Chen, Conxi Lázaro, Celeste L. Pearce, Hoda Anton-Culver, Study Collaborators Gemo, Aleksandra Gentry-Maharaj, Malcolm C. Pike, Patricia Harrington, Gerry Coetzee, Agnieszka Dansonka-Mieszkowska, Houtan Noushmehr, Jolanta Kupryjanczyk, Kenneth Offit, Matt Freedman, the Consortium of Investigators of Modifiers of Brca1 and Brca2, Australian Cancer Study (Ovarian Investigators), Douglas F. Easton, Paul Pp Pharoah, Fergus J. Couch, Australian Ovarian Cancer Study Group, Simon Gayther, Antonis C. Antoniou, Estrid Høgdall, Georgia Chenevix-Trench, Anne-Bine Semma Skytte members of-) Consortium of Investigators of Modifiers of Brca1 and BRCA2 (CIMBA) (Lone Sunde, Eva Machackova

Show less

This paper is made freely available by the publisher.

Full text: Download

Preprint: archiving allowed

Upload

Postprint: archiving restricted

Upload

Published version: archiving forbidden

Policy details

Data provided by

Abstract

Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.

Published in

Links

Tools

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

Abstract