Nano gamma alumina (NGA) was prepared via a simple synthetic route and used for the preparation of a nanofluid in various salinity on the water-wet sandstone core samples. A new waterflooding experiment on sandstone rock for enhanced oil recovery (EOR) has been used by taking into account at different water salinities. In this paper, the impressiveness of a new EOR process in the presence of alumina-based nanofluids to alter the dynamic adsorption of sandstone core sample in low salinity and high salinity brine injection has been experimentally studied. The nanofluids with suitable concentration of NGA particles and salinities in ranging from 2000 ppm to 200000 ppm and 25-80 oC were prepared. Results showed the reduced adsorption by the use of nanoparticles at low salinity conditions. The ultimately optimum recoveries for 2000, 20000, and 200000 ppm of nanofluids injection were obtained as 56.95%, 64.78%, and 71.48%, respectively. It was found that these oil recoveries depend strongly on the concentration of salinities and were increased with decreasing salinity loading. Therefore, the dynamic adsorption behavior of nanofluids results shows a key role in clay migration in oil displacement.