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American Chemical Society, ACS Symposium Series, p. 95-112, 1999

DOI: 10.1021/bk-1999-0731.ch008

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Quantitation in the Analysis of Oligomers by HPLC with Evaporative Light Scattering Detector

Journal article published in 1999 by Bernd Trathnigg, Manfred Kollroser, Dušan Berek, Son Hoai Nguyen, David Hunkeler
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The performance of the evaporative light scattering detector (ELSD) in the analysis of polyethers is critically evaluated with respect to quantitative reliability. A comparison of three different types of instruments with a different design shows, that all of them do not fulfil the expectations of chromatographers and the promises of producers: their response depends quite strongly on mobile phase composition. This problem can be overcome by combination of the ELSD with a density detector.