Other ; Background: Prior to the recent Ebola Virus Disease (EVD) outbreak, the pediatric age-group remained largely minimally affected or undetected/unreported. Given magnitude of this outbreak there has been a considerable proportion of children infected. This historical perspective may have limited inter-epidemic introduction of pediatric-specific treatment guidelines whereby clinical care was based on consultation of adult guidelines. There are limited studies analyzing pediatric clinical outcomes in EVD. In current study, we describe age-specific mortality and predictors of clinical outcomes of EVD in two districts where transmission happened in distinct phases and successive time periods. Conclusion: The high peadiatric mortality and deeper analysis of mortality findings in this study have not been documented before. Except the higher probability and shorter duration to death in this study, other findings are comparable with most of tropical diseases. The belated introduction of pediatric clinical guidelines which coincided with EVD introduction in Western District did not reverse pediatric deaths.