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Springer Nature [academic journals on nature.com], International Journal of Obesity, 2(39), p. 312-320, 2014

DOI: 10.1038/ijo.2014.122

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Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin.

Journal article published in 2014 by Chiara Alfarano, Camille Foussal, Olivier Lairez, Denis Calise, Camille Attané, Rodica Anesia, Danièle Daviaud, Estelle Wanecq, Angelo Parini ORCID, Philippe Valet, Oksana Kunduzova ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background/Objectives:Impaired energy metabolism is the defining characteristic of obesity-related heart failure. The adipocyte-derived peptide apelin has a role in the regulation of cardiovascular and metabolic homeostasis and may contribute to the link between obesity, energy metabolism and cardiac function. Here we investigate the role of apelin in the transition from metabolic adaptation to maladaptation of the heart in obese state.Methods:Adult male C57BL/6J, apelin knock-out (KO) or wild-type mice were fed a high-fat diet (HFD) for 18 weeks. To induce heart failure, mice were subjected to pressure overload after 18 weeks of HFD. Long-term effects of apelin on fatty acid (FA) oxidation, glucose metabolism, cardiac function and mitochondrial changes were evaluated in HFD-fed mice after 4 weeks of pressure overload. Cardiomyocytes from HFD-fed mice were isolated for analysis of metabolic responses.Results:In HFD-fed mice, pressure overload-induced transition from hypertrophy to heart failure is associated with reduced FA utilization (P