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Hindawi, Journal of Immunology Research, (2015), p. 1-12, 2015

DOI: 10.1155/2015/680749

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TRAIL Modulates the Immune System and Protects against the Development of Diabetes

Journal article published in 2015 by Fleur Bossi, Stella Bernardi ORCID, Giorgio Zauli, Paola Secchiero, Bruno Fabris
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

TRAIL or tumor necrosis factor (TNF) related apoptosis-inducing ligand is a member of the TNF superfamily of proteins, whose best characterized function is the induction of apoptosis in tumor, infected, or transformed cells through activation of specific receptors. In nontransformed cells, however, the actions of TRAIL are less well characterized. Recent studies suggest that TRAIL may be implicated in the development and progression of diabetes. Here we review TRAIL biological actions, its effects on the immune system, and how and to what extent it has been shown to protect against diabetes.