Published in
Elsevier, Tetrahedron, 25(57), p. 5421-5428
DOI: 10.1016/s0040-4020(01)00461-6
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Preparation of a- and b-Substituted Alanine Derivatives by a-Amidoalkylation or Michael Addition Reactions under Heterogeneous Catalysis Assisted by Microwave Irradiation
Journal article published in 2001 by
Antonio de la Hoz 
,
Angel Diaz-Ortiz,
M. V. Gómez,
Marı́a Victoria Gómez,
José Antonio Mayoral,
J. A. Mayoral,
Andres Moreno,
Ana Marı́a Sanchez-Migallon ,
Ester Vazquez,
Ester Vázquez
,
Angel Diaz-Ortiz,
M. V. Gómez,
Marı́a Victoria Gómez,
José Antonio Mayoral,
J. A. Mayoral,
Andres Moreno,
Ana Marı́a Sanchez-Migallon ,
Ester Vazquez,
Ester Vázquez
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Abstract
Silica-supported Lewis acids are useful catalysts in conjunction with microwave irradiation for the synthesis of a range of alanine derivatives. Reaction of methyl α-acetamidoacrylate (1) with different heterocycles, such as furan (2), pyrrole (3), N-benzylpyrrole (4), indole (5) and pyrazole (6) and the carbocycle 1,3,5-trihydroxybenzene (7), led to several α-amino acid precursors.