Published in
Royal Society of Chemistry, RSC Advances, 46(6), p. 39636-39641, 2016
DOI: 10.1039/c6ra06403e
Links
Tools
A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity
Journal article published in 2016 by
Massimiliano Cuccioloni,
Laura Bonfili,
Matteo Mozzicafreddo 
,
Valentina Cecarini,
Riccardo Pettinari,
Francesca Condello,
Claudio Pettinari ,
Fabio Marchetti,
Mauro Angeletti,
Anna Maria Eleuteri
,
Valentina Cecarini,
Riccardo Pettinari,
Francesca Condello,
Claudio Pettinari ,
Fabio Marchetti,
Mauro Angeletti,
Anna Maria Eleuteri
This paper is made freely available by the publisher.
Full text: Download
Preprint: archiving forbidden
Data provided by 
Abstract
A ruthenium(II) p-cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells.