Royal Society of Chemistry, RSC Advances, 46(6), p. 39636-39641, 2016
DOI: 10.1039/c6ra06403e
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A ruthenium(II) p-cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells.