Dissemin is shutting down on January 1st, 2025

Published in

American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 10(59), p. 6625-6628, 2015

DOI: 10.1128/aac.01275-15

Links

Tools

Export citation

Search in Google Scholar

Characterization of an Enterobacter cloacae Strain Producing both KPC and NDM Carbapenemases by Whole-Genome Sequencing

Journal article published in 2015 by Wenjing Wu, Yu Feng, Alessandra Carattoli ORCID, Zhiyong Zong ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Orange circle
Published version: archiving restricted
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

ABSTRACT A carbapenem-resistant Enterobacter cloacae strain, WCHECl-14653, causing a fatal bloodstream infection, was characterized by genome sequencing and conjugation experiments. The strain carried two carbapenemase genes, bla NDM-1 and bla KPC-2 , on separate IncF plasmids. The coexistence of bla NDM-1 and bla KPC-2 conferred slightly higher-level carbapenem resistance compared with that of bla NDM-1 or bla KPC-2 alone, and the coexistence of two IncF plasmids may generate new platforms for spreading carbapenemase genes.