We demonstrate the feasibility of a 16x3.75 Gb/s (60 Gb/s aggregate) Orthogonal frequency division multiplexing - Code division multiple access passive optical network (OFDM-CDMA PON) for next-generation access applications. Error-free transmission of four 3.75 Gb/s PON channels over 25 km SMF shows 0.1 dB dispersion and 0.9 dB crosstalk penalties. Advantages of the system include high capacity, enhanced spectral efficiency, coding gain, networking functions such as increased security and single wavelength operation.