Published in

Springer, International Journal of Clinical Pharmacy, 2016

DOI: 10.1007/s11096-016-0285-6

Links

Tools

Export citation

Search in Google Scholar

Medication safety research by observational study design

Journal article published in 2016 by Kim S. J. Lao, S. Lao, Celine S. L. Chui, Slc Chui ORCID, Kenneth K. C. Man, Wallis C. Y. Lau, Cy Lau, Esther W. Chan, Ian C. K. Wong
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Observational studies have been recognised to be essential for investigating the safety profile of medications. Numerous observational studies have been conducted on the platform of large population databases, which provide adequate sample size and follow-up length to detect infrequent and/or delayed clinical outcomes. Cohort and case-control are well-accepted traditional methodologies for hypothesis testing, while within-individual study designs are developing and evolving, addressing previous known methodological limitations to reduce confounding and bias. Respective examples of observational studies of different study designs using medical databases are shown. Methodology characteristics, study assumptions, strengths and weaknesses of each method are discussed in this review.