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Optica, Biomedical Optics Express, 10(3), p. 2500, 2012

DOI: 10.1364/boe.3.002500

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Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics

Journal article published in 2012 by Rudolf Alwi, Sergey Telenkov, Andreas Mandelis, Timothy Leshuk, Frank Gu ORCID, Sulayman Oladepo, Kirk Michaelian
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In this study, we report for the first time the use of silica-coated superparamagnetic iron oxide nanoparticles (SPION) as contrast agents in biomedical photoacoustic imaging. Using frequency-domain photoacoustic correlation (the photoacoustic radar), we investigated the effects of nanoparticle size, concentration and biological media (e.g. serum, sheep blood) on the photoacoustic response in turbid media. Maximum detection depth and the minimum measurable SPION concentration were determined experimentally. The nanoparticle-induced optical contrast ex vivo in dense muscular tissues (avian pectus and murine quadricept) was evaluated and the strong potential of silica-coated SPION as a possible photoacoustic contrast agents was demonstrated.