Published in
BioMed Central, Immunity and Ageing, 1(13), 2016
DOI: 10.1186/s12979-016-0059-y
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Tools
Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study
,
Heiner Boeing,
Stein Emil Vollset,
Øivind Midttun,
Per Magne Ueland,
Bas Bueno-De-Mesquita,
Martin Lajous,
Guy Fagherazzi,
Marie-Christine Boutron-Ruault,
Rudolf Kaaks,
Tilman Küehn,
Tobias Pischon ,
Dagmar Drogan,
Anne Tjønneland
and other authors.
Full text: Download
Abstract
Background: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p