Published in
Sociedade Brasileira de Microbiologia, Brazilian Journal of Microbiology, 3(45), p. 929-932
DOI: 10.1590/s1517-83822014000300023
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Whole cells in enantioselective reduction of benzyl acetoacetate
Journal article published in 2014 by
Aline de Souza Ramos,
Joyce Benzaquem Ribeiro,
Raquel de Oliveira Lopes,
Rodrigo Octavio Mendonça Alves de Souza,
Gabriela Veloso Vieira da Silva,
Aline de Souza Ramos 
,
Raquel de Oliveira Lopes,
Gabriela Veloso Vieira da Silva,
Rodrigo Octavio Mendonça Alves de Souza
,
Raquel de Oliveira Lopes,
Gabriela Veloso Vieira da Silva,
Rodrigo Octavio Mendonça Alves de Souza
This paper is made freely available by the publisher.
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Abstract
The β-ketoester benzyl acetoacetate was enantioselectively reduced to benzyl (S)-3-hydroxybutanoate by seven microorganism species. The best result using free cells was obtained with the yeast Hansenula sp., which furnished 97% ee and 85% of conversion within 24 h. After immobilization in calcium alginate spheres, K.marxianus showed to be more stable after 2 cycles of reaction.