Cold Spring Harbor Laboratory Press, Genes & Development, 13(24), p. 1334-1338, 2010
DOI: 10.1101/gad.1946810
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Understanding exactly how chromatin is assembled is paramount to addressing how select histone modifications may be transmitted, a putative epigenetic process. In the June 15, 2010, issue of Genes & Development, Drané and colleagues (pp. 1253–1265) identified DAXX as a novel H3.3-specific chaperone. This finding, in the context of others published by Goldberg and colleauges in Cell and Sawatsubashi and colleagues (pp. 159–170) in the January 15, 2010, issue of Genes & Development, provides the impetus for uncovering the mechanistic and functional properties of alternative histone deposition pathways.