Published in

Centers for Disease Control and Prevention, Emerging Infectious Diseases, 3(18), p. 449-457, 2012

DOI: 10.3201/eid1803.110728

Links

Tools

Export citation

Search in Google Scholar

Lineage-specific Virulence Determinants ofHaemophilus influenzaeBiogroup aegyptius

Journal article published in 2012 by Fiona R. Strouts, Peter Power, Nicholas J. Croucher ORCID, Nicola Corton, Andries van Tonder, Michael A. Quail, Paul R. Langford, Michael J. Hudson, Julian Parkhill ORCID, J. Simon Kroll, Stephen D. Bentley
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

An emergent clone of Haemophilus influenzae biogroup aegyptius (Hae) is responsible for outbreaks of Brazilian purpuric fever (BPF). First recorded in Brazil in 1984, the so-called BPF clone of Hae caused a fulminant disease that started with conjunctivitis but developed into septicemic shock; mortality rates were as high as 70%. To identify virulence determinants, we conducted a pan-genomic analysis. Sequencing of the genomes of the BPF clone strain F3031 and a noninvasive conjunctivitis strain, F3047, and comparison of these sequences with 5 other complete H. influenzae genomes showed that >77% of the F3031 genome is shared among all H. influenzae strains. Delineation of the Hae accessory genome enabled characterization of 163 predicted protein-coding genes; identified differences in established autotransporter adhesins; and revealed a suite of novel adhesins unique to Hae, including novel trimeric autotransporter adhesins and 4 new fimbrial operons. These novel adhesins might play a critical role in host-pathogen interactions.