Published in
Centers for Disease Control and Prevention, Emerging Infectious Diseases, 3(18), p. 449-457, 2012
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- Centers for Disease Control and Prevention
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- [hdl.handle.net]
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [citeseerx.ist.psu.edu] | PDF
- [spiral.imperial.ac.uk] | PDF
Tools
Lineage-specific Virulence Determinants ofHaemophilus influenzaeBiogroup aegyptius
,
Nicola Corton,
Andries van Tonder,
Michael A. Quail,
Paul R. Langford,
Michael J. Hudson,
Julian Parkhill ,
J. Simon Kroll,
Stephen D. Bentley
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Abstract
An emergent clone of Haemophilus influenzae biogroup aegyptius (Hae) is responsible for outbreaks of Brazilian purpuric fever (BPF). First recorded in Brazil in 1984, the so-called BPF clone of Hae caused a fulminant disease that started with conjunctivitis but developed into septicemic shock; mortality rates were as high as 70%. To identify virulence determinants, we conducted a pan-genomic analysis. Sequencing of the genomes of the BPF clone strain F3031 and a noninvasive conjunctivitis strain, F3047, and comparison of these sequences with 5 other complete H. influenzae genomes showed that >77% of the F3031 genome is shared among all H. influenzae strains. Delineation of the Hae accessory genome enabled characterization of 163 predicted protein-coding genes; identified differences in established autotransporter adhesins; and revealed a suite of novel adhesins unique to Hae, including novel trimeric autotransporter adhesins and 4 new fimbrial operons. These novel adhesins might play a critical role in host-pathogen interactions.