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Nature Research, Nature Genetics, 7(46), p. 701-706, 2014

DOI: 10.1038/ng.3012

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Genome and transcriptome of the porcine whipworm Trichuris suis

Journal article published in 2014 by Aaron R. Jex, Peter Nejsum ORCID, Erich M. Schwarz, Li Hu, Neil D. Young ORCID, Ross S. Hall, Pasi K. Korhonen, Shengguang Liao, Stig Milan Thamsborg, Jinquan Xia, Pengwei Xu, Shaowei Wang, Jean-Pierre Y. Scheerlinck, Andreas Hofmann ORCID, Paul W. Sternberg and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at ~140-fold coverage of adult male and female T. suis and ~80-Mb draft assemblies. We explore stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs.