Dissemin is shutting down on January 1st, 2025

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Elsevier, Annals of Oncology, 3(25), p. 618-623, 2014

DOI: 10.1093/annonc/mdt528

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Association of molecular subtypes with Ki-67 changes in untreated breast cancer patients undergoing pre-surgical trials

Journal article published in 2014 by S. Gandini, A. Guerrieri-Gonzaga, G. Pruneri, D. Serrano ORCID, M. Cazzaniga, M. Lazzeroni, P. Veronesi, H. Johansson, B. Bonanni, G. Viale, A. DeCensi
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Abstract

Ki-67 is increasingly being used as a response biomarker in window of opportunity trials for breast cancer. We analyzed 274 patients who received no active treatment in pre-surgical trials and noticed a significant increase in Ki-67 from baseline biopsy to end point surgery in HER2-positive and triple-negative tumors. This association suggests a real increase in cancer proliferation and should be considered in the design and interpretation of pre-surgical studies.