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Royal Society of Chemistry, Chemical Science, 4(7), p. 2674-2678, 2016

DOI: 10.1039/c5sc04501k

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Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(III) and Eu(III) ions for specific sensing of a viral RNA

Journal article published in 2016 by Cristina Penas, Jose Luis Mascareñas ORCID, M. Eugenio Vázquez ORCID, M. Eugenio Vázquez
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Rational modification of a natural RNA-binding peptide with a lanthanide EDTA chelator, and a phenanthroline ligand yields a highly selective luminescent sensor. The sensing mechanism relies on the RNA-triggered folding of the peptide into a β-hairpin, which promotes the coordination of the phenanthroline sensitizer, and the efficient sensitization of the complexed lanthanide ions.