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Elsevier, Molecular Metabolism, 6(5), p. 379-391, 2016

DOI: 10.1016/j.molmet.2016.03.003

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PI3K p110β subunit in Leptin Receptor Expressing Cells is Required for the Acute Hypophagia Induced by Endotoxemia

Journal article published in 2016 by Beatriz C. Borges, David Garcia-Galiano ORCID, Rodrigo Rorato, Lucila L.-K. Elias, Carol F. Elias
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Hypophagia and increased energy expenditure under inflammatory conditions, such as that observed after bacterial lipopolysaccharide (LPS) administration, are associated with leptin secretion. The hypophagic effect of leptin depends in part on the activation of PI3K signaling pathway. However, the role of PI3K in the endotoxemia-induced hypophagia has not been determined.