Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Berndt, Sonja I.; Sonja I. Berndt, A.; and Susan L. Slager, † and Susan L. Slager; Nicola J. Camp, * Nicola J. Camp; Joseph Vijai, *.; Camp, Nicola J.; Zhaoming Wang, *.; Skibola, Christine F.; Jian Gu, *.; Vijai, Joseph; Rachel S. Kelly, 8. Rachel S. Kelly; Wang, Zhaoming; Karin E. Smedby, 10 Karin E. Smedby; Gu, Jian; Wendy Cozen, 14; Nieters, Alexandra; Sophia S. Wang, 17 Sophia S. Wang; Kelly, Rachel S.; Qing Lan, 18; Smedby, Karin E.; Lauren R. Teras, 1. Lauren R. Teras; Monnereau, Alain; Cozen, Wendy; Moara Machado, 19; Meredith Yeager, 20; Cox, Angela; Patricia Hartge, 22; Wang, Sophia S.; Lan, Qing; Mark P. Purdue, 1. Mark P. Purdue; Teras, Lauren R.; Pierluigi Cocco, 25; Machado, Moara; Yawei Zhang, 26; Yeager, Meredith; Graham G. Giles, 27 Graham G. Giles; Rebecca Montalvan, 33; Brooks Wilson, Angela R.; Hartge, Patricia; Laurie Burdett, 33; Yuanqing Ye, 6.; Purdue, Mark P.; Timothy G. Call, 7. Timothy G. Call; Birmann, Brenda M.; Tait D. Shanafelt, 34 Tait D. Shanafelt; Vajdic, Claire M.; Neil E. Kay, 35 Neil E. Kay; Cocco, Pierluigi; Mark Liebow, 34; Zhang, Yawei; Giles, Graham G.; Julie M. Cunningham, 35 Julie M. Cunningham; Cristine Allmer, 36; Zeleniuch-Jacquotte, Anne; Henrik Hjalgrim, 37; Lawrence, Charles; Hans-Olov Adami, 38; Montalvan, Rebecca; Mads Melbye, 39; Burdett, Laurie; Ellen T. Chang, 41 Ellen T. Chang; Hutchinson, Amy; Martha Glenn, 43; Ye, Yuanqing; Karen Curtin, 44; Call, Timothy G.; Lisa A. Cannon-Albright, 45 Lisa A. Cannon-Albright; Shanafelt, Tait D.; Ryan Diver, 46 W.; Novak, Anne J.; George J. Weiner, 47 George J. Weiner; Kay, Neil E.; Lucia Conde, 47; Liebow, Mark; Paige M. Bracci, 4. Paige M. Bracci; Cunningham, Julie M.; Jacques Riby, 48; Allmer, Cristine; Donna K. Arnett, 4. Donna K. Arnett; Hjalgrim, Henrik; Degui Zhi, 3.; Adami, Hans-Olov; Justin M. Leach, 49 Justin M. Leach; Melbye, Mads; Elizabeth A. Holly, 49 Elizabeth A. Holly; Glimelius, Bengt; Rebecca D. Jackson, 48 Rebecca D. Jackson; Chang, Ellen T.; Lesley F. Tinker, 50 Lesley F. Tinker; Glenn, Martha; Yolanda Benavente, 51; Curtin, Karen; Núria Sala, 53; Cannon Albright, Lisa A.; Delphine Casabonne, 55; Diver, W. Ryan; Nikolaus Becker, 57; Link, Brian K.; Paolo Boffetta, 58; Weiner, George J.; Paul Brennan, 59; Conde, Lucia; Lenka Foretova, 60; Bracci, Paige M.; Marc Maynadie, 61; Riby, Jacques; James McKay, 62; Arnett, Donna K.; Kari G. Chaffee, 63 Kari G. Chaffee; Zhi, Degui; Sara J. Achenbach, 37 Sara J. Achenbach; Leach, Justin M.; Lynn R. Goldin, 37 Lynn R. Goldin; Holly, Elizabeth A.; Sara S. Strom, 1. Sara S. Strom; Jackson, Rebecca D.; Jose F. Leis, 7. Jose F. Leis; Tinker, Lesley F.; Neil E. Caporaso, 65 Neil E. Caporaso; Benavente, Yolanda; Lindsay M. Morton, 66 Lindsay M. Morton; Sala, Núria; Richard K. Severson, 1. Richard K. Severson; Casabonne, Delphine; Elio Riboli, 67; Becker, Nikolaus; Paolo Vineis, 68; Boffetta, Paolo; Rudolph Kaaks, 69; Brennan, Paul; Giovanna Masala, 58; Foretova, Lenka; Elisabete Weiderpass, 70; Maynadie, Marc; María-Dolores Chirlaque, 73; McKay, James; Roel C. H. Vermeulen, 74 Roel C. H. Vermeulen; Staines, Anthony; Ruth C. Travis, 76 Ruth C. Travis; Chaffee, Kari G.; Melissa C. Southey, 77 Melissa C. Southey; Achenbach, Sara J.; Vachon, Celine M.; Roger L. Milne, 78 Roger L. Milne; Goldin, Lynn R.; Demetrius Albanes, 29; Strom, Sara S.; Leis, Jose F.; Jarmo Virtamo, 1.; Weinberg, J. Brice; Stephanie Weinstein, 79; Jacqueline Clavel, 1.; Caporaso, Neil E.; Norman, Aaron D.; De Roos, Anneclaire J.; Tongzhang Zheng, 13; Morton, Lindsay M.; Theodore R. Holford, 27 Theodore R. Holford; Severson, Richard K.; Danylo J. Villano, 80 Danylo J. Villano; Riboli, Elio; John J. Spinelli, 5. John J. Spinelli; Vineis, Paolo; Randy D. Gascoyne, 82 Randy D. Gascoyne; Kaaks, Rudolph; Joseph M. Connors, 84 Joseph M. Connors; Masala, Giovanna; Kimberly A. Bertrand, 85 Kimberly A. Bertrand; Weiderpass, Elisabete; Edward Giovannucci, 24; Peter Kraft, 86; Chirlaque, María-Dolores; Vermeulen, Roel C. H.; Jenny Turner, 88; Travis, Ruth C.; Maria Grazia Ennas, 90; Southey, Melissa C.; Giovanni M. Ferri, 91 Giovanni M. Ferri; Milne, Roger L.; Lucia Miligi, 92; Liming Liang, 93; Albanes, Demetrius; Virtamo, Jarmo; Jinyan Huang, 94; Weinstein, Stephanie; Simon Crouch, 9.; Ju-Hyun Park, 95; Clavel, Jacqueline; Zheng, Tongzhang; Nilanjan Chatterjee, 96; Holford, Theodore R.; Kari E. North, 1. Kari E. North; Villano, Danylo J.; John A. Snowden, 98 John A. Snowden; Maria, Ann; Josh Wright, 99; Spinelli, John J.; Joseph F. Fraumeni, 99 Joseph F. Fraumeni; Gascoyne, Randy D.; Kenneth Offit, 1.; Connors, Joseph M.; Xifeng Wu, 5.; Silvia de Sanjose, †.; Bertrand, Kimberly A.; Giovannucci, Edward; James R. Cerhan, † James R. Cerhan; Kraft, Peter; Stephen J. Chanock, † Stephen J. Chanock; Kricker, Anne; Nathaniel Rothman, †.; Turner, Jenny; Christine F. Skibola, * Christine F. Skibola; Ennas, Maria Grazia; Alexandra Nieters, *.; Ferri, Giovanni M.; Alain Monnereau, 11; Miligi, Lucia; Angela Cox, 16; Liang, Liming; Angela R. Brooks-Wilson, 6. Angela R. Brooks-Wilson; Ma, Baoshan; Brenda M. Birmann, 23 Brenda M. Birmann; Huang, Jinyan; Claire M. Vajdic, 24 Claire M. Vajdic; Crouch, Simon; Anne Zeleniuch-Jacquotte, 29; Park, Ju-Hyun; Charles Lawrence, 32; Chatterjee, Nilanjan; Amy Hutchinson, 6.; North, Kari E.; Anne J. Novak, 35 Anne J. Novak; Snowden, John A.; Bengt Glimelius, 40; Wright, Josh; Brian K. Link, 19 Brian K. Link; Fraumeni, Joseph F.; Anthony Staines, 60; Offit, Kenneth; Celine M. Vachon, 37 Celine M. Vachon; Wu, Xifeng; Brice Weinberg, 64 J.; de Sanjose, Silvia; Aaron D. Norman, 1. Aaron D. Norman; Anneclaire J. De Roos, 37 Anneclaire J. De Roos; Cerhan, James R.; Ann Maria, 5.; Chanock, Stephen J.; Rothman, Nathaniel; Anne Kricker, 87; Baoshan, 87; Slager, Susan L.; Albanese, Demetrius

Dissemin
Brenda Birmann
Berndt et al., 2016

Published in

Nature Research, Nature Communications, 1(7), 2016

DOI: 10.1038/ncomms10933

Tools

Export citation

Format

@article{Berndt2016,
 abstract = {AbstractChronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10−11), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10−8) and 3q28 (rs9815073, LPP, P=3.62 × 10−8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10−11) in the combined analysis. We find suggestive evidence (P&lt;5 × 10−7) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10−8) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10−7). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.},
 author = {Berndt, Sonja I. and Sonja I. Berndt, A. and and Susan L. Slager, † and Susan L. Slager and Nicola J. Camp, * Nicola J. Camp and Joseph Vijai, *. and Camp, Nicola J. and Zhaoming Wang, *. and Skibola, Christine F. and Jian Gu, *. and Vijai, Joseph and Rachel S. Kelly, 8. Rachel S. Kelly and Wang, Zhaoming and Karin E. Smedby, 10 Karin E. Smedby and Gu, Jian and Wendy Cozen, 14 and Nieters, Alexandra and Sophia S. Wang, 17 Sophia S. Wang and Kelly, Rachel S. and Qing Lan, 18 and Smedby, Karin E. and Lauren R. Teras, 1. Lauren R. Teras and Monnereau, Alain and Cozen, Wendy and Moara Machado, 19 and Meredith Yeager, 20 and Cox, Angela and Patricia Hartge, 22 and Wang, Sophia S. and Lan, Qing and Mark P. Purdue, 1. Mark P. Purdue and Teras, Lauren R. and Pierluigi Cocco, 25 and Machado, Moara and Yawei Zhang, 26 and Yeager, Meredith and Graham G. Giles, 27 Graham G. Giles and Rebecca Montalvan, 33 and Brooks Wilson, Angela R. and Hartge, Patricia and Laurie Burdett, 33 and Yuanqing Ye, 6. and Purdue, Mark P. and Timothy G. Call, 7. Timothy G. Call and Birmann, Brenda M. and Tait D. Shanafelt, 34 Tait D. Shanafelt and Vajdic, Claire M. and Neil E. Kay, 35 Neil E. Kay and Cocco, Pierluigi and Mark Liebow, 34 and Zhang, Yawei and Giles, Graham G. and Julie M. Cunningham, 35 Julie M. Cunningham and Cristine Allmer, 36 and Zeleniuch-Jacquotte, Anne and Henrik Hjalgrim, 37 and Lawrence, Charles and Hans-Olov Adami, 38 and Montalvan, Rebecca and Mads Melbye, 39 and Burdett, Laurie and Ellen T. Chang, 41 Ellen T. Chang and Hutchinson, Amy and Martha Glenn, 43 and Ye, Yuanqing and Karen Curtin, 44 and Call, Timothy G. and Lisa A. Cannon-Albright, 45 Lisa A. Cannon-Albright and Shanafelt, Tait D. and Ryan Diver, 46 W. and Novak, Anne J. and George J. Weiner, 47 George J. Weiner and Kay, Neil E. and Lucia Conde, 47 and Liebow, Mark and Paige M. Bracci, 4. Paige M. Bracci and Cunningham, Julie M. and Jacques Riby, 48 and Allmer, Cristine and Donna K. Arnett, 4. Donna K. Arnett and Hjalgrim, Henrik and Degui Zhi, 3. and Adami, Hans-Olov and Justin M. Leach, 49 Justin M. Leach and Melbye, Mads and Elizabeth A. Holly, 49 Elizabeth A. Holly and Glimelius, Bengt and Rebecca D. Jackson, 48 Rebecca D. Jackson and Chang, Ellen T. and Lesley F. Tinker, 50 Lesley F. Tinker and Glenn, Martha and Yolanda Benavente, 51 and Curtin, Karen and Núria Sala, 53 and Cannon Albright, Lisa A. and Delphine Casabonne, 55 and Diver, W. Ryan and Nikolaus Becker, 57 and Link, Brian K. and Paolo Boffetta, 58 and Weiner, George J. and Paul Brennan, 59 and Conde, Lucia and Lenka Foretova, 60 and Bracci, Paige M. and Marc Maynadie, 61 and Riby, Jacques and James McKay, 62 and Arnett, Donna K. and Kari G. Chaffee, 63 Kari G. Chaffee and Zhi, Degui and Sara J. Achenbach, 37 Sara J. Achenbach and Leach, Justin M. and Lynn R. Goldin, 37 Lynn R. Goldin and Holly, Elizabeth A. and Sara S. Strom, 1. Sara S. Strom and Jackson, Rebecca D. and Jose F. Leis, 7. Jose F. Leis and Tinker, Lesley F. and Neil E. Caporaso, 65 Neil E. Caporaso and Benavente, Yolanda and Lindsay M. Morton, 66 Lindsay M. Morton and Sala, Núria and Richard K. Severson, 1. Richard K. Severson and Casabonne, Delphine and Elio Riboli, 67 and Becker, Nikolaus and Paolo Vineis, 68 and Boffetta, Paolo and Rudolph Kaaks, 69 and Brennan, Paul and Giovanna Masala, 58 and Foretova, Lenka and Elisabete Weiderpass, 70 and Maynadie, Marc and María-Dolores Chirlaque, 73 and McKay, James and Roel C. H. Vermeulen, 74 Roel C. H. Vermeulen and Staines, Anthony and Ruth C. Travis, 76 Ruth C. Travis and Chaffee, Kari G. and Melissa C. Southey, 77 Melissa C. Southey and Achenbach, Sara J. and Vachon, Celine M. and Roger L. Milne, 78 Roger L. Milne and Goldin, Lynn R. and Demetrius Albanes, 29 and Strom, Sara S. and Leis, Jose F. and Jarmo Virtamo, 1. and Weinberg, J. Brice and Stephanie Weinstein, 79 and Jacqueline Clavel, 1. and Caporaso, Neil E. and Norman, Aaron D. and De Roos, Anneclaire J. and Tongzhang Zheng, 13 and Morton, Lindsay M. and Theodore R. Holford, 27 Theodore R. Holford and Severson, Richard K. and Danylo J. Villano, 80 Danylo J. Villano and Riboli, Elio and John J. Spinelli, 5. John J. Spinelli and Vineis, Paolo and Randy D. Gascoyne, 82 Randy D. Gascoyne and Kaaks, Rudolph and Joseph M. Connors, 84 Joseph M. Connors and Masala, Giovanna and Kimberly A. Bertrand, 85 Kimberly A. Bertrand and Weiderpass, Elisabete and Edward Giovannucci, 24 and Peter Kraft, 86 and Chirlaque, María-Dolores and Vermeulen, Roel C. H. and Jenny Turner, 88 and Travis, Ruth C. and Maria Grazia Ennas, 90 and Southey, Melissa C. and Giovanni M. Ferri, 91 Giovanni M. Ferri and Milne, Roger L. and Lucia Miligi, 92 and Liming Liang, 93 and Albanes, Demetrius and Virtamo, Jarmo and Jinyan Huang, 94 and Weinstein, Stephanie and Simon Crouch, 9. and Ju-Hyun Park, 95 and Clavel, Jacqueline and Zheng, Tongzhang and Nilanjan Chatterjee, 96 and Holford, Theodore R. and Kari E. North, 1. Kari E. North and Villano, Danylo J. and John A. Snowden, 98 John A. Snowden and Maria, Ann and Josh Wright, 99 and Spinelli, John J. and Joseph F. Fraumeni, 99 Joseph F. Fraumeni and Gascoyne, Randy D. and Kenneth Offit, 1. and Connors, Joseph M. and Xifeng Wu, 5. and Silvia de Sanjose, †. and Bertrand, Kimberly A. and Giovannucci, Edward and James R. Cerhan, † James R. Cerhan and Kraft, Peter and Stephen J. Chanock, † Stephen J. Chanock and Kricker, Anne and Nathaniel Rothman, †. and Turner, Jenny and Christine F. Skibola, * Christine F. Skibola and Ennas, Maria Grazia and Alexandra Nieters, *. and Ferri, Giovanni M. and Alain Monnereau, 11 and Miligi, Lucia and Angela Cox, 16 and Liang, Liming and Angela R. Brooks-Wilson, 6. Angela R. Brooks-Wilson and Ma, Baoshan and Brenda M. Birmann, 23 Brenda M. Birmann and Huang, Jinyan and Claire M. Vajdic, 24 Claire M. Vajdic and Crouch, Simon and Anne Zeleniuch-Jacquotte, 29 and Park, Ju-Hyun and Charles Lawrence, 32 and Chatterjee, Nilanjan and Amy Hutchinson, 6. and North, Kari E. and Anne J. Novak, 35 Anne J. Novak and Snowden, John A. and Bengt Glimelius, 40 and Wright, Josh and Brian K. Link, 19 Brian K. Link and Fraumeni, Joseph F. and Anthony Staines, 60 and Offit, Kenneth and Celine M. Vachon, 37 Celine M. Vachon and Wu, Xifeng and Brice Weinberg, 64 J. and de Sanjose, Silvia and Aaron D. Norman, 1. Aaron D. Norman and Anneclaire J. De Roos, 37 Anneclaire J. De Roos and Cerhan, James R. and Ann Maria, 5. and Chanock, Stephen J. and Rothman, Nathaniel and Anne Kricker, 87 and Baoshan, 87 and Slager, Susan L. and Albanese, Demetrius},
 doi = {10.1038/ncomms10933},
 journal = {Nature Communications},
 month = {mar},
 title = {Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia},
 url = {https://www.nature.com/articles/ncomms10933.pdf},
 volume = {7},
 year = {2016}
}

Download

Export citation

Search in Google Scholar

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Journal article published in 2016 by Sonja I. Berndt, A. Sonja I. Berndt, † and Susan L. Slager and Susan L. Slager, * Nicola J. Camp Nicola J. Camp, *. Joseph Vijai, Nicola J. Camp, *. Zhaoming Wang, Christine F. Skibola, *. Jian Gu, Joseph Vijai

, 8. Rachel S. Kelly Rachel S. Kelly, Zhaoming Wang, 10 Karin E. Smedby Karin E. Smedby, Jian Gu, 14 Wendy Cozen and other authors. Sonja I. Berndt, A. Sonja I. Berndt, † and Susan L. Slager and Susan L. Slager, * Nicola J. Camp Nicola J. Camp, *. Joseph Vijai, Nicola J. Camp, *. Zhaoming Wang, Christine F. Skibola, *. Jian Gu, Joseph Vijai

, 8. Rachel S. Kelly Rachel S. Kelly, Zhaoming Wang, 10 Karin E. Smedby Karin E. Smedby, Jian Gu, 14 Wendy Cozen, Alexandra Nieters, 17 Sophia S. Wang Sophia S. Wang, Rachel S. Kelly, 18 Qing Lan, Karin E. Smedby, 1. Lauren R. Teras Lauren R. Teras, Alain Monnereau, Wendy Cozen, 19 Moara Machado, 20 Meredith Yeager, Angela Cox

, 22 Patricia Hartge, Sophia S. Wang, Qing Lan, 1. Mark P. Purdue Mark P. Purdue, Lauren R. Teras, 25 Pierluigi Cocco, Moara Machado, 26 Yawei Zhang, Meredith Yeager, 27 Graham G. Giles Graham G. Giles, 33 Rebecca Montalvan, Angela R. Brooks Wilson, Patricia Hartge, 33 Laurie Burdett, 6. Yuanqing Ye, Mark P. Purdue, 7. Timothy G. Call Timothy G. Call, Brenda M. Birmann

, 34 Tait D. Shanafelt Tait D. Shanafelt, Claire M. Vajdic

, 35 Neil E. Kay Neil E. Kay, Pierluigi Cocco, 34 Mark Liebow, Yawei Zhang, Graham G. Giles

, 35 Julie M. Cunningham Julie M. Cunningham, 36 Cristine Allmer, Anne Zeleniuch-Jacquotte

, 37 Henrik Hjalgrim, Charles Lawrence, 38 Hans-Olov Adami, Rebecca Montalvan, 39 Mads Melbye, Laurie Burdett, 41 Ellen T. Chang Ellen T. Chang, Amy Hutchinson, 43 Martha Glenn, Yuanqing Ye, 44 Karen Curtin, Timothy G. Call, 45 Lisa A. Cannon-Albright Lisa A. Cannon-Albright, Tait D. Shanafelt, 46 W. Ryan Diver, Anne J. Novak, 47 George J. Weiner George J. Weiner, Neil E. Kay, 47 Lucia Conde, Mark Liebow, 4. Paige M. Bracci Paige M. Bracci, Julie M. Cunningham

, 48 Jacques Riby, Cristine Allmer, 4. Donna K. Arnett Donna K. Arnett, Henrik Hjalgrim, 3. Degui Zhi, Hans-Olov Adami, 49 Justin M. Leach Justin M. Leach, Mads Melbye, 49 Elizabeth A. Holly Elizabeth A. Holly, Bengt Glimelius, 48 Rebecca D. Jackson Rebecca D. Jackson, Ellen T. Chang, 50 Lesley F. Tinker Lesley F. Tinker, Martha Glenn, 51 Yolanda Benavente, Karen Curtin, 53 Núria Sala, Lisa A. Cannon Albright, 55 Delphine Casabonne, W. Ryan Diver, 57 Nikolaus Becker, Brian K. Link

, 58 Paolo Boffetta, George J. Weiner, 59 Paul Brennan, Lucia Conde, 60 Lenka Foretova, Paige M. Bracci, 61 Marc Maynadie, Jacques Riby, 62 James McKay, Donna K. Arnett, 63 Kari G. Chaffee Kari G. Chaffee, Degui Zhi, 37 Sara J. Achenbach Sara J. Achenbach, Justin M. Leach, 37 Lynn R. Goldin Lynn R. Goldin, Elizabeth A. Holly, 1. Sara S. Strom Sara S. Strom, Rebecca D. Jackson, 7. Jose F. Leis Jose F. Leis, Lesley F. Tinker, 65 Neil E. Caporaso Neil E. Caporaso, Yolanda Benavente, 66 Lindsay M. Morton Lindsay M. Morton, Núria Sala, 1. Richard K. Severson Richard K. Severson, Delphine Casabonne, 67 Elio Riboli, Nikolaus Becker, 68 Paolo Vineis, Paolo Boffetta, 69 Rudolph Kaaks, Paul Brennan, 58 Giovanna Masala, Lenka Foretova, 70 Elisabete Weiderpass, Marc Maynadie, 73 María-Dolores Chirlaque, James McKay, 74 Roel C. H. Vermeulen Roel C. H. Vermeulen, Anthony Staines

, 76 Ruth C. Travis Ruth C. Travis, Kari G. Chaffee

, 77 Melissa C. Southey Melissa C. Southey, Sara J. Achenbach, Celine M. Vachon, 78 Roger L. Milne Roger L. Milne, Lynn R. Goldin, 29 Demetrius Albanes, Sara S. Strom, Jose F. Leis, 1. Jarmo Virtamo, J. Brice Weinberg, 79 Stephanie Weinstein, 1. Jacqueline Clavel, Neil E. Caporaso, Aaron D. Norman, Anneclaire J. De Roos, 13 Tongzhang Zheng, Lindsay M. Morton, 27 Theodore R. Holford Theodore R. Holford, Richard K. Severson, 80 Danylo J. Villano Danylo J. Villano, Elio Riboli, 5. John J. Spinelli John J. Spinelli, Paolo Vineis, 82 Randy D. Gascoyne Randy D. Gascoyne, Rudolph Kaaks, 84 Joseph M. Connors Joseph M. Connors, Giovanna Masala

, 85 Kimberly A. Bertrand Kimberly A. Bertrand, Elisabete Weiderpass, 24 Edward Giovannucci, 86 Peter Kraft, María-Dolores Chirlaque, Roel C. H. Vermeulen, 88 Jenny Turner, Ruth C. Travis, 90 Maria Grazia Ennas, Melissa C. Southey, 91 Giovanni M. Ferri Giovanni M. Ferri, Roger L. Milne, 92 Lucia Miligi, 93 Liming Liang, Demetrius Albanes, Jarmo Virtamo, 94 Jinyan Huang, Stephanie Weinstein, 9. Simon Crouch, 95 Ju-Hyun Park, Jacqueline Clavel, Tongzhang Zheng, 96 Nilanjan Chatterjee, Theodore R. Holford, 1. Kari E. North Kari E. North, Danylo J. Villano, 98 John A. Snowden John A. Snowden, Ann Maria, 99 Josh Wright, John J. Spinelli, 99 Joseph F. Fraumeni Joseph F. Fraumeni, Randy D. Gascoyne, 1. Kenneth Offit, Joseph M. Connors, 5. Xifeng Wu, †. Silvia de Sanjose, Kimberly A. Bertrand, Edward Giovannucci, † James R. Cerhan James R. Cerhan, Peter Kraft, † Stephen J. Chanock Stephen J. Chanock, Anne Kricker, †. Nathaniel Rothman, Jenny Turner, * Christine F. Skibola Christine F. Skibola, Maria Grazia Ennas, *. Alexandra Nieters, Giovanni M. Ferri

, 11 Alain Monnereau, Lucia Miligi, 16 Angela Cox, Liming Liang, 6. Angela R. Brooks-Wilson Angela R. Brooks-Wilson, Baoshan Ma, 23 Brenda M. Birmann Brenda M. Birmann, Jinyan Huang

, 24 Claire M. Vajdic Claire M. Vajdic, Simon Crouch, 29 Anne Zeleniuch-Jacquotte, Ju-Hyun Park, 32 Charles Lawrence, Nilanjan Chatterjee, 6. Amy Hutchinson, Kari E. North, 35 Anne J. Novak Anne J. Novak, John A. Snowden, 40 Bengt Glimelius, Josh Wright, 19 Brian K. Link Brian K. Link, Joseph F. Fraumeni, 60 Anthony Staines, Kenneth Offit, 37 Celine M. Vachon Celine M. Vachon, Xifeng Wu, 64 J. Brice Weinberg, Silvia de Sanjose, 1. Aaron D. Norman Aaron D. Norman, 37 Anneclaire J. De Roos Anneclaire J. De Roos, James R. Cerhan, 5. Ann Maria, Stephen J. Chanock, Nathaniel Rothman, 87 Anne Kricker, 87 Baoshan, Susan L. Slager, Demetrius Albanese

Show less

This paper is made freely available by the publisher.

Full text: Download

Preprint: archiving allowed

Upload

Postprint: archiving forbidden

Published version: archiving allowed

Upload

Policy details

Data provided by

Abstract

AbstractChronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10⁻¹¹), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10⁻⁸) and 3q28 (rs9815073, LPP, P=3.62 × 10⁻⁸), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10⁻¹¹) in the combined analysis. We find suggestive evidence (P<5 × 10⁻⁷) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10⁻⁸) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10⁻⁷). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.

Published in

Links

Tools

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Abstract