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BioMed Central, Lipids in Health and Disease, 1(15), 2016

DOI: 10.1186/s12944-016-0224-5

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SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects

Journal article published in 2016 by Nasser M. Al Daghri, Abdul Khader Mohammed ORCID, Omar S. Al Attas, Osama E. Amer, Mario Clerici, Amal Alenad, Majed S. Alokail
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Irisin is a recently identified myokine that plays an important role in preventing obesity and insulin resistance. We investigated whether the common FNDC5 (irisin precursor) gene variants influence susceptibility to obesity and type 2 diabetes (T2D) and verified the impact of FNDC5 gene variants on serum irisin levels, glucose and lipid metabolism in a Saudi population. Methods Genomic DNA from 814 (394 T2DM and 414 controls) subjects were genotyped for the five common SNPs (rs3480A/G, rs1746661G/T, rs1298190A/G, rs726344A/G and rs1570569G/T) of the FNDC5 gene using the TaqMan genotyping assay. Biochemical parameters and hematic concentrations of irisin and insulin as well as anthropometric indices were collected. Results Serum irisin levels were higher in T2DM patients compared to controls (p