Published in
Lippincott, Williams & Wilkins, Psychiatric Genetics, 6(21), p. 319-322, 2011
DOI: 10.1097/ypg.0b013e3283463deb
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Copy number variations in affective disorders and meta-analysis
,
Srdjan Djurovic,
Eva Haastrup,
Anders Albrecthsen,
Louise K. E. Hoeffding,
Anna Secher,
Omar Gustafsson,
Klaus D. Jakobsen,
Finn C. Nielsen,
Henrik Ullum,
Gunnar Morken,
Ingrid Agartz,
Ingrid Melle,
Ulrik Gether
and other authors.
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Abstract
In two recent studies 10 copy number variants (CNV) were found to be overrepresented either among patients suffering from affective disorders in an Amish family or in the Wellcome Trust Case-Control Consortium study. Here, we investigate if these variants are associated with affective disorders in a combined analysis of three case-control samples from Denmark, Norway and Iceland. A total of 1897 cases (n=1223 unipolar and n=463 bipolar) and 11 231 controls were analyzed for CNVs at the 10 genomic loci, but we found no combined association between these CNVs and affective disorders.