Society of Nuclear Medicine, Journal of Nuclear Medicine, 10(54), p. 1812-1819, 2013
DOI: 10.2967/jnumed.113.119776
Full text: Download
Research and discovery (R&D) of novel radiopharmaceuticals and targets thereof generally involves initial studies in cell cultures, followed by animal studies, both of which present several inherent limitations. The objective of this work was to develop a tissue bioreactor (TBR) enabling modulation of the microenvironment and to integrate the TBR with the microPET Focus F220 to facilitate imaging biomarker R&D and validation of radiopharmaceuticals.