This special issue of Mechanics of AdvancedMaterials and Structures (MAMS) collects selected articles on the application of the Carrera Unified Formulation (CUF) and advanced theories for solving different problems with particular emphasis on multilayered structures. CUF is a hierarchical formulation allowing for a straightforward implementation of advanced structural theories and it has acquired particular interest in recent years. This special issue focuses the attentionontheuseofCUFwith the following numerical techniques: finite element method (FEM), generalized differential quadrature (GDQ) method, radial basis function (RBF) method, dynamic stiffness matrix (DSM) method, Ritz and Navier methods.