The emerging of new technologies (e.g., motion sensors) has enabled the creation of more realistic games. Due to its playful feature, these games have been successfully applied in health care, mainly as a supplementary therapy for rehabilitation treatments. There are many areas where games are, and can be, applied. In this sense, for a better understanding of the use of games in healthcare, we carried out a literature review to verify the different possibilities of use and its benefits. We performed a systematic review of literature which reveals that the best results, and areas where the games are most used, are in the rehabilitation of patients with brain damage, cerebral palsy, the reduction of fall's risk and therapies for overweight people. These results can be applied as requirements for researches and developments for healthcare.