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Public Library of Science, PLoS ONE, 3(11), p. e0150483, 2016

DOI: 10.1371/journal.pone.0150483

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Performance of Different Analytical Software Packages in Quantification of DNA Methylation by Pyrosequencing

Journal article published in 2016 by Chiara Grasso, Morena Trevisan, Valentina Fiano ORCID, Valentina Tarallo, Laura De Marco, Carlotta Sacerdote, Lorenzo Richiardi, Franco Merletti, Anna Gillio-Tos
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Pyrosequencing has emerged as an alternative method of nucleic acid sequencing, well suited for many applications which aim to characterize single nucleotide polymorphisms, mutations, microbial types and CpG methylation in the target DNA. The commercially available pyrosequencing systems can harbor two different types of software which allow analysis in AQ or CpG mode, respectively, both widely employed for DNA methylation analysis.