Lack of correlation of spirometry or total smoking history with lung AMø TLR3 expresssion in surgical cohort. Total lung Mø were harvested from excess lung tissue removed surgically for clinical indications as decribed in the legend to Figure 3. Lung Mø were permeabilized, stained for TLR3 expression and analyzed by flow cytometry, gating on CD45+, high side-scatter cells. Data are shown as the percentage of TLR3-positive lung Mø on the vertical axis versus A, FEV1 % predicted; B, smoking history in pack-years. In panel A, circles represent current smokers and “x” respresents former smokers. In panel B, all subjects are shown as inverted triangles, regardless of smoking status (active vs. former); in both panels, n = 25.