This article describes the recruitment and retention methods of chiropractors who participated in three projects in a practice-based research program and reports on a survey of their opinions and experiences. Participants were recruited through the assistance of professional leaders, chiropractic publications, and personal communication with program staff. Retention methods included providing training to chiropractors and their staff, mailing summary reports following each project, certificates of appreciation to chiropractors and staff, chiropractors' names being included in the acknowledgments of the published articles, and continued personal contact with the program coordinator. A total of 289 chiropractors from 236 practices located in 44 states, Canada, and Australia participated in the program. Of the 266 mailed surveys, 216 (81%) were returned. Most of the respondents reported that both they and their patients had a positive experience with research as a result of their participation, although time was identified as the largest barrier to their involvement. Factors that impact participation in practice-based research include support from professional leaders, project content, and the amount of disruption to the practice due to project demands.