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Taylor and Francis Group, Nucleosides, Nucleotides and Nucleic Acids, 3(30), p. 203-209, 2011

DOI: 10.1080/15257770.2011.563765

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A Mathematical Model of Human Thymidine Kinase 2 Activity

Journal article published in 2011 by T. Radivoyevitch ORCID, B. Munch-Petersen, L. Wang, S. Eriksson
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ~0.5 (apparent negative cooperativity) for dT and ~1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.