Published ; Journal Article ; Review ; Meiotic drivers are genetic variants that selfishly manipulate the production of gametes to increase their own rate of transmission, often to the detriment of the rest of the genome and the individual that carries them. This genomic conflict potentially occurs whenever a diploid organism produces a haploid stage, and can have profound evolutionary impacts on gametogenesis, fertility, individual behaviour, mating system, population survival, and reproductive isolation. Multiple research teams are developing artificial drive systems for pest control, utilising the transmission advantage of drive to alter or exterminate target species. Here, we review current knowledge of how natural drive systems function, how drivers spread through natural populations, and the factors that limit their invasion. ; This review was written at the Ecology of Meiotic Drive workshop, with funding from the Swiss National Science Foundation (IZ32Z0_160288), the Russian Science Foundation (15-29-02550), the Department of Evolutionary Biology and Environmental Studies (University of Zurich), and the Vereinigung akademischer Mittelbau der Universität Zürich