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Springer Nature [academic journals on nature.com], Cell Death and Disease, 2(7), p. e2097-e2097, 2016

DOI: 10.1038/cddis.2015.411

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Extracellular ATP and P2X7 receptor exert context-specific immunogenic effects after immunogenic cancer cell death

Journal article published in 2016 by Abhishek D. Garg ORCID, Dmitri V. Krysko, Peter Vandenabeele, Patrizia Agostinis
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Immunogenic cell death (ICD) facilitates danger signalling-driven trafficking of damage-associated molecular patterns (DAMPs) like extracellular ATP (eATP). The binding of eATP to P2X7 receptor triggers immunogenic signalling, which (along with other factors) converts the dying cancer cells into an effective anticancer vaccine. Type II and Type I ICD inducers differ on several levels, for example, plasticity of danger signalling and the trafficking mechanisms of DAMPs. In fact, eATP was found to be absent during Newcastle disease virus (NDV)-induced Type II ICD despite the induction of macroautophagy (a Type I ICD-associated, eATP-trafficking mechanism). Moreover, we have established that Hyp-PDT-induced eATP is PERK and secretory pathway-dependent, while being independent of macroautophagy or chaperone-mediated autophagy. This raised an important question – like in the case of NDV-induced ICD, could eATP be dispensable or a partial immunogenic signal for Hyp-PDT-induced ICD?