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Taylor and Francis Group, Cell Cycle, 7(10), p. 1031-1036

DOI: 10.4161/cc.10.7.15067

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Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia

Journal article published in 2011 by Teresa D’Altri ORCID, Jessica Gonzalez, Iannis Aifantis, Lluis Espinosa, Anna Bigas
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Notch activation is a current event in T Acute Lymphoblastic Leukemia (T-ALL) but the downstream elements that are able to support Notch-dependent leukemias are not well characterized. We have recently shown that the Notch-Hes1-CYLD-NFkB axis is crucial in the maintenance of T-ALL, but detailed evaluation of the contribution of each one of these elements is still missing. Here we use a Notch1-induced leukemia in vivo model to study the effect of silencing the Notch-target gene, Hes1, or over-expressing the Hes1-target, CYLD. We here show that both strategies completely abolish the ability of constitutive active Notch1 to generate T-ALL.