Published in

Elsevier, Biochemical and Biophysical Research Communications, 1(355), p. 240-244

DOI: 10.1016/j.bbrc.2007.01.143

Links

Tools

Export citation

Search in Google Scholar

β-catenin/TCF/LEF regulate expression of the short form human Cripto-1.

Journal article published in 2007 by Shin Hamada, Kazuhide Watanabe, Morihisa Hirota ORCID, Caterina Bianco, Luigi Strizzi, Mario Mancino ORCID, Monica Gonzales, David S. Salomon
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-catenin/TCF signaling pathway, also express CR-1. Expression of a short form of CR-1 mRNA in colon carcinoma and hepatoma cell lines suggests that there may be differential regulation of CR-1 expression by the canonical Wnt signaling pathway in colon cancer as well as hepatoma cell lines. The present study demonstrates a direct transcriptional regulation of the short form CR-1 expression by the canonical Wnt signaling pathway through an intronic-exonic enhancer element, containing three tandem TCF/LEF binding sites within the CR-1 gene.