Association of Forced Vital Capacity with the Developmental Gene NCOR2

Wain, L.; Minelli, Cosetta; Dean, Charlotte H.; Alves, Alexessander Couto; Hind, Matthew; Wareham, N. J.; Wang, X.-Q.; Amaral, André F. S.; Siroux, Valerie and Huikari Ville; Huikari, Ville; Gharib, S. A.; Vitart,; Franceschini, N.; Koch, B.; Trochet, H.; Pottinger, T. D.; Wilk, J. B.; Smith, A.; Duan, Q.; Thyagarajan, B.; Oldmeadow, C.; Loth, Daan W.; Lee, M. K.; Couto, Alves Alexessander; Artigas, María Soler; Viñuela, A.; Strachan, D. P.; Evans, David M.; Wright, A. F.; James, A. L.; Huffman, J. E.; Ramasamy, A.; Kaprio, J.; Thompson, John; Postma, Dirkje S.; Kähönen, M.; Wojczynski, M.; Flexeder, C.; Albrecht, E.; Wild, S. H.; Sin, Don and Thompson John; Bossé, Yohan; Lopez, L. M.; De Jong, K.; Enroth, S.; Omenaas, E.; White, W. B.; Joshi, P. K.; Fall, T.; Launer, L. J.; Völzke, H.; Loehr, L. R.; Bouzigon, Emmanuelle; Fornage, M.; Demenais, Florence; Li, G.; Jarvis, Deborah; Zgaga, L.; Tang, W.; Manichaikul, A.; Henderson, John; Lahousse, L.; Uitterlinden, A. G.; Järvelin, Marjo-Riitta; Harris, T. B.; Zhao, J. H.; North, K. E.; Rudnicka, A. R.; Burney, Peter; Van Meurs, J. B. J.; Hui, J.; Gu, X.; Wijmenga, C.; Soler Artigas, María; Lumley, T.; Hastie, N. D.; Campbell, S.; Kumar, R.; Pin, I.; Scott, R. A.; Williams, O.; Pietiläinen, K. H.; Zemunik, T.; Surakka, I.; Liu, Y.; Wjst, M.; W., Loth Daan; Holliday, E. G.; Schulz, H.; Heinrich, J.; Davies, G.; MVonk, J.; Pouta, A.; Johansson, Å.; Wilson, J. F.; Viljanen, A.; Ingelsson, E.; Rivadeneira, F.; Hysi, P. G.; Eiriksdottir, G.; Morrison, A. C.; Rotter, J. I.; Gao, W.; Rich, S. S.; Hofman, A.; Aspelund, T.; Couper, D.; Tobin,; Smith, L. J.; Psaty, B. M.; Lohman, K.; Burchard, E. G.; Garcia, M.; Joubert, B. R.; McArdle, W. L.; Musk,; Hansel, N.; Heckbert,; Navarro, P.; Rudan, I.; Oh, Y.-M.; Redline, S.; Rantanen, T.; O. Connor, G. T.; Ripatti, S.; Scott, R. J.; Jarvis, Deborah L.; Karrasch, S.; Grallert, H.; Gaddis, N. C.; MStarr, J.; Minster, R. L.; Lederer, D. J.; Pekkanen, J.; Gyllensten, U.; Campbell, H.; Morris, A. P.; Gläser, S.; Hammond, C. J.; MBurkart, K.; Beilby, J.; Kritchevsky, S. B.; Gudnason,; Hancock, D. B.; Polasek, O.; Kolcic, I.; Petrini,; Kim, W. J.; Porteous, D. J.; Scotland, G.; Smith, B. H.; Jarvelin, Marjo-Riitta; Heliövaara, M.; Attia,; Sayers, I.; Hampel, R.; Gieger, C.; Consortium, SpiroMeta; Deary, I. J.; Boezen, H. M.; Newman, A.; Lind, L.; Stricker, B. H.; Teumer, A.; Spector, T. D.; Charge, Consortium; Melén, E.; Peters, M. J.; Lange, L. A.; Barr, R. G.; Bracke, K. R.; MVerhamme, F.; Sung, J.; Hiemstra, P. S.; Cassano, P. A.; Sood, A.; Hayward, C.; Dupuis, J.; Hall, I. P.; Brusselle, G. G.; London, S. J.

Published in

Public Library of Science, PLoS ONE, 2(11), p. e0147388, 2016

DOI: 10.1371/journal.pone.0147388

Tools

Export citation

Search in Google Scholar

Association of Forced Vital Capacity with the Developmental Gene NCOR2

Journal article published in 2016 by L. Wain, Cosetta Minelli, Charlotte H. Dean, Alexessander Couto Alves, Matthew Hind, N. J. Wareham, X.-Q. Wang, André F. S. Amaral, Valerie and Huikari Ville Siroux

, Ville Huikari, S. A. Gharib, Vitart, N. Franceschini, B. Koch, H. Trochet and other authors.

This paper is made freely available by the publisher.

Full text: Download

Preprint: archiving allowed

Upload

Postprint: archiving allowed

Upload

Published version: archiving allowed

Upload

Policy details

Data provided by

Abstract

Public Library of Science open access ; BACKGROUND: Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly heritable, a small number of genes have been found associated with FVC, and we aimed at identifying further genetic variants by focusing on lung development genes. METHODS: Per-allele effects of 24,728 SNPs in 403 genes involved in lung development were tested in 7,749 adults from three studies (NFBC1966, ECRHS, EGEA). The most significant SNP for the top 25 genes was followed-up in 46,103 adults (CHARGE and SpiroMeta consortia) and 5,062 children (ALSPAC). Associations were considered replicated if the replication p-value survived Bonferroni correction (p

Published in

Links

Tools

Association of Forced Vital Capacity with the Developmental Gene NCOR2

Abstract